Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy
Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy
复制标题
西维来司他对胸段食管癌术后呼吸系统疾病的预防作用
DOI：
10.1007/s00595-013-0508-6
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发表时间：
2013
期刊：
影响因子：
2.5
通讯作者：
H. Baba
中科院分区：
文献类型：
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作者：
Y. Nagai;Masayuki Watanabe;Y. Baba;M. Iwatsuki;K. Hirashima;R. Karashima;J. Kurashige;K. Kinoshita;H. Baba
目的西维来司他是一种选择性中性粒细胞弹性蛋白酶抑制剂，可减轻全身炎症反应综合征相关的急性肺损伤。本研究回顾性调查西维来司他对呼吸功能的影响在接受食管切除术的患者。MethodsPatients谁接受食管切除术胸段食管癌2005年至2010年被纳入本研究。42例患者在围手术期接受西维来司他（4.8 mg/kg/d;西维来司他组）治疗，其余35例患者未接受西维来司他治疗（对照组）。从手术开始至术后第3天连续给予西维来司他。所有患者均给予甲基强的松龙治疗3天。比较两组患者围术期临床及实验室资料、序贯器官衰竭总评分、PaO 2/FiO 2比值（P/F比值）及术后并发症情况。西维来司他组术后即刻P/F比显著高于对照组（p < 0.05）。西维来司他组术后即刻呼吸频率和术后第2天体温明显低于对照组（p < 0.05）。其他临床数据或并发症中没有差异。ConclusionsPerioperative管理sivelestat改善食管切除术后患者的术后呼吸功能。
PurposeSivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy.MethodsPatients who underwent esophagectomy for thoracic esophageal cancer between 2005 and 2010 were included in this study. Forty-two were treated perioperatively with sivelestat (4.8 mg/kg/day; sivelestat group) and the remaining 35 were not (control group). Sivelestat was administered continuously from the beginning of surgery until postoperative day 3. All patients were administered methylprednisolone for 3 days. The perioperative clinical and laboratory data, total sequential organ failure assessment score, PaO2/FiO2 ratio (P/F ratio) and postoperative complications were compared between the two groups.ResultsThere were no significant differences between the groups in the patients’ background data. The P/F ratio immediately after surgery was significantly higher in the sivelestat group than in the control group (p < 0.05). The respiratory rate immediately after surgery and the temperature on postoperative day 2 were significantly lower in the sivelestat group than in the control group (p < 0.05). There were no differences in any of the other clinical data or complications.ConclusionsPerioperative administration of sivelestat improves postoperative respiratory function in patients after esophagectomy.
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影响因子：
3.8
作者：
Morita, Masaru;Yoshida, Rintaro;Maehara, Yoshihiko
通讯作者：
Maehara, Yoshihiko
影响因子：
9
作者：
Sato, N;Koeda, K;Endo, S
通讯作者：
Endo, S
中性粒细胞弹性蛋白酶抑制剂改善胸段食管切除术后的术后临床过程
DOI：
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发表时间：
2007
期刊：
Dis Esophagus 20
影响因子：
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作者：
Suda K;Kitagawa Y;Ozawa S;Miyasho T;Okamoto M;Saikawa Y;Ueda M;Yamada S;Tasaka S;Funakoshi Y;Hashimoto S;Yokota H;Maruyama I;Ishizaka A;Kitajima M
通讯作者：
Kitajima M
武田，S.，金，C.，池崎，H.，中西，K.，坂本，A.，大川，K.，宫下，M.，笹岛，K.，田尻，T.，田中，K.，
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