Histone methylation in transcriptional control
Histone methylation in transcriptional control
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DOI：
10.1016/s0959-437x(02)00287-3
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发表时间：
2002-04-01
影响因子：
4
通讯作者：
Kouzarides, T
中科院分区：
文献类型：
--
作者：
Kouzarides, T
在过去的一年左右，历史的甲基化已经被认为是基因活性调节的主要参与者。这一概念是在发现赖氨酸和精氨酸甲基转移酶以及识别历史上甲基赖氨酸“标记”的蛋白质之后提出的。甲基化的历史已经涉及异染色质阻遏、启动子调控和通过DNA甲基化的阻遏状态的传播。
Over the past year or so, methylation of histories has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyllysine 'mark' on histories. Methylated histories have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.