TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes.
TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes.
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DOI：
10.1182/blood-2013-01-477349
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发表时间：
2013-05
期刊：
影响因子：
20.3
通讯作者：
Shuyang Yu;Hai-hui Xue
中科院分区：
文献类型：
--
作者：
Shuyang Yu;Hai-hui Xue
致编辑：Notch衍生的信号对于造血祖细胞向T细胞谱系的特化和对于促进在CD 4-CD 8-双阴性3（DN 3）阶段的β-选择是必需的。然而，这些信号并不是胸腺细胞进一步成熟所必需的。[1][2]因此，
To the editor: Notch-derived signals are essential for specification of hematopoietic progenitors to T-cell lineage and for promotion of β-selection at the CD4–CD8– double-negative 3 (DN3) stage. However, these signals are not required for further thymocyte maturation.[1][1] Accordingly, the