Effects of nitrovasodilators, endothelium-dependent vasodilators, and atrial peptides on cGMP.
Effects of nitrovasodilators, endothelium-dependent vasodilators, and atrial peptides on cGMP.
复制标题
硝基血管扩张剂、内皮依赖性血管扩张剂和心房肽对 cGMP 的影响。
DOI：
10.1101/sqb.1988.053.01.115
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Kohse,K
中科院分区：
文献类型：
--
作者：
Murad,F;Leitman,D;Waldman,S;Chang,CH;Hirata,M;Kohse,K
随着20世纪60年代鸟苷酸环化酶- cgmp系统的发现，人们预计该系统将成为类似于腺苷酸环化酶- camp系统的重要信号转导和第二信使系统。然而，支持这一假设的数据仅在过去的5-10年才出现。本文综述了本实验室和其他实验室的一些研究，这些研究使我们对cGMP的合成及其在平滑肌松弛中的作用有了目前的认识，更具体地说，它介导了几种血管扩张剂的作用。最近对几种模型系统中cGMP合成的调控及其一些影响进行了一些详细的审查（更详细的讨论，见Murad 1986； Leitman and Murad 1987; Waldman and Murad 1987；以及其中的参考文献）。
With the discovery of the guanylate cyclase-cGMP system in the 1960s, it was anticipated that this system would serve as an important signal transduction and second-messenger system analogous to the adenylate cyclase-cAMP system. However, data to support this hypothesis have only been forthcoming during the past 5-10 years. This paper reviews some of the studies from this laboratory and others that have led to our present understanding of the synthesis of cGMP and its role in smooth muscle relaxation and more specifically its role to mediate the effects of several classes of vasodilators. The regulation of the synthesis of cGMP and some of its effects in several model systems have recently been reviewed in some detail (for a more detailed discussion, see Murad 1986; Leitman and Murad 1987; Waldman and Murad 1987; and the references therein).