Regional size reduction in the human corpus callosum following pre- and perinatal brain injury
Regional size reduction in the human corpus callosum following pre- and perinatal brain injury
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DOI：
10.1093/cercor/10.12.1200
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发表时间：
2000-12-01
期刊：
影响因子：
3.7
通讯作者：
Edwards, E
中科院分区：
文献类型：
--
作者：
Moses, P;Courchesne, E;Edwards, E
这项形态计量学研究考察了两个方面的胼胝体发育：儿科皮质-胼胝体地形图和围产期脑损伤后发育的神经可塑性。对10例局灶性病变儿童和86例健康志愿者进行了在体磁共振成像定量研究，测量了10例局灶性病变儿童和86例健康志愿者的总矢状面面积和5个前后区的大小。在早期受伤的10名儿童中，有9名显示出与匹配的对照组相比，骨痂总面积减少。其总横切面面积与病变大小成反比。所有患者均表现为区域特异性大小缩小。这种区域变薄与病变部位有一定的地形关系。前亚区1、2和3的缩小分别与额前下区、额中上区和中央前区的病变有关。4区病变减弱对应于前顶叶病变，5区变薄与后顶叶损伤相对应。这种皮质-胼胝体模式与成年和非人类灵长类动物的映射一致。尽管病变起病较早，但膝盖骨变薄提示发育神经可塑性受限。
This morphometric study examined two aspects of corpus callosum development: pediatric cortico-callosal topography and developmental neuroplasticity subsequent to perinatal brain injury. In vivo magnetic resonance imaging was used to quantify the total midsagittal cross-sectional area and five anterioposterior subregions of the callosum in 10 children with focal lesions and 86 healthy volunteer control subjects. Nine of the ten children with early injury showed a reduction in the total area of the callosum relative to matched controls. The area of the total callosum cross-section was inversely proportional to the size of lesion. All patients displayed region-specific size reduction. This regional thinning bore a topographical relationship to the lesion sites. Reduction in anterior subregions 1, 2 and 3 was respectively associated with lesions in the anterior inferior frontal area, the middle and superior frontal region, and the precentral area. Attenuation of subregion 4 corresponded to anterior parietal lesions, and thinning of subregion 5 occurred with posterior parietal injury. This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity.