Arteriolar vascular smooth muscle cells: mechanotransducers in a complex environment.
Arteriolar vascular smooth muscle cells: mechanotransducers in a complex environment.
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DOI：
10.1016/j.biocel.2012.05.021
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Meininger GA
中科院分区：
文献类型：
--
作者：
Hill MA;Meininger GA
小动脉(直径通常小于250μm)的收缩通过对血管管径的影响，在局部控制血流和动脉压方面起着关键作用。具体地说，小动脉因腔内压力增加而收缩，被称为肌源性反应，代表了机械转导的重要作用。VSMC如何感知压力的变化并通过细胞膜传递以调节细胞的收缩状态，这些关键问题仍然存在。最近的研究表明，VSMCs和细胞外基质(ECM)蛋白之间的相互作用起着关键作用。因此，压力诱导的ECM蛋白及其细胞表面受体(例如整合素)的变形可能通过调节离子通道、膜去极化、细胞内钙离子增加和肌动蛋白交叉桥循环来启动收缩和细胞骨架重构。重要的是，有人认为小动脉VSMCs的收缩特性反映了它们与细胞外环境和管壁三维结构的密切和完整的相互作用。
Contraction of small artery (diameters typically less than 250 μm) vascular smooth muscle cells (VSMCs) plays a critical role in local control of blood flow and arterial pressure through its affect on vascular caliber. Specifically, contraction of small arteries in response to increased intraluminal pressure is referred to as the myogenic response and represents an important role for mechanotransduction. Critical questions remain as to how changes in pressure are sensed by VSMCs and transduced across the cell membrane to tune the contractile state of the cell. Recent studies suggest a pivotal role for interactions between VSMCs and extracellular matrix (ECM) proteins. Thus, pressure-induced deformation of ECM proteins and their cell surface receptors (for example, integrins) may initiate contraction and cytoskeletal remodeling through modulation of ion channels, membrane depolarization, increased intracellular Ca2+ and actomyosin crossbridge cycling. Importantly, it is argued that the contractile properties of small artery VSMCs reflect an intimate and integrated interaction with their extracellular environment and the three-dimensional structure of the vessel wall.
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影响因子：
8.3
作者：
Cipolla, MJ;McCall, AL;Porter, JM
通讯作者：
Porter, JM
影响因子：
--
作者：
LIU, J;HILL, MA;MEININGER, GA
通讯作者：
MEININGER, GA
影响因子：
20.1
作者：
Bakker, ENTP;Buus, CL;VanBavel, E
通讯作者：
VanBavel, E
影响因子：
4.8
作者：
Loufrani, L;Matrougui, K;Henrion, D
通讯作者：
Henrion, D
DOI：
10.1152/ajpheart.00441.2001
发表时间：
2002-04-01
影响因子：
4.8
作者：
Gokina, NI;Osol, G
通讯作者：
Osol, G