Reductive coupling of terpenic allylic halides catalyzed by CP2TiCl:: A short and efficient asymmetric synthesis of onocerane triterpenes
Reductive coupling of terpenic allylic halides catalyzed by CP2TiCl:: A short and efficient asymmetric synthesis of onocerane triterpenes
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DOI：
10.1021/ol050335r
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发表时间：
2005-06-09
期刊：
影响因子：
5.2
通讯作者：
Sánchez, EM
中科院分区：
文献类型：
--
作者：
Barrero, AF;Herrador, MM;Sánchez, EM
二茂钛氯化物催化萜烯烯丙基卤化物的区域选择性 α,α'-自偶联。该工艺已用于快速有效地合成萜类化合物，例如 β-onocerdiene (1)、β-onocerin (2) 和角鲨烯 (3)。有证据表明 eta(1)-烯丙基钛物质参与了偶联。
Titanocene chloride catalyzes the regioselective alpha,alpha '-homocoupling of terpenic allylic halides. This process has been employed in the short and effective synthesis of terpenoids such as beta-onoceradiene (1), beta-onocerin (2), and squalene (3). Evidence is presented for eta(1)-allyltitanium species being involved in the coupling.