Thermogenesis, food intake and serum leptin in cold-exposed lactating Brandt's voles Lasiopodomys brandtii
Thermogenesis, food intake and serum leptin in cold-exposed lactating Brandt's voles Lasiopodomys brandtii
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DOI：
10.1242/jeb.02659
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发表时间：
2007-02-01
影响因子：
2.8
通讯作者：
Wang, De-Hua
中科院分区：
文献类型：
--
作者：
Zhang, Xue-Ying;Wang, De-Hua
哺乳期是哺乳动物能量消耗最高的时期，与新陈代谢和能量摄入增加有关，但产热能力下降。众所周知，小型哺乳动物在寒冷时会增加食物摄入量和产热作用。本研究旨在研究布氏田鼠 Lasiopodomysbrandtii 是否可以调整能量摄入和生热作用以适应同时哺乳和寒冷暴露。将田鼠置于两种温度处理中：温暖（23 +/- 1 摄氏度）和寒冷（5 +/- 1 摄氏度）。在每个温度处理下的动物进一步分为两组：非繁殖性（NR）组和哺乳期雌性组。我们发现，与温暖环境下的相比，寒冷环境下泌乳高峰期的哺乳田鼠食物摄入量增加了 2.6 g day(-1)，并且棕色脂肪组织 (BAT) 中解偶联蛋白 1 (UCP1) 含量增加，达到与寒冷暴露的 NR 雌性相同的水平。哺乳期血清瘦素水平显着下降，且与体重和脂肪量呈正相关。校正体重影响后，残留血清瘦素与残留总能量摄入和残留 RMR 呈负相关。此外，在温暖环境下，残余血清瘦素水平与UCP1含量呈正相关，但在寒冷环境下则不然。总之，这些数据表明，哺乳期田鼠可以增加产热能力和能量摄入，以满足同时哺乳和寒冷暴露的高能量成本。此外，血清瘦素似乎参与能量摄入调节和体温调节，但寒冷时的体温调节可能主要由其他因素介导。
Lactation is the most energetically expensive period for mammals and is associated with increased metabolism and energy intake, but decreased thermogenic capacity. It is well known that small mammals increase both food intake and thermogenesis in the cold. The present study aimed to examine whether Brandt's voles Lasiopodomys brandtii could adjust energy intake and thermogenesis to accommodate simultaneous lactation and cold exposure. The voles were placed into two temperature treatments: warm (23 +/- 1 degrees C) and cold (5 +/- 1 degrees C). Animals at each temperature treatment were further divided into two groups: non-reproductive (NR) and lactating females. We found that lactating voles at peak lactation in the cold enhanced food intake by 2.6 g day(-1) compared with those in the warm, and increased uncoupling protein 1 (UCP1) content in brown adipose tissue (BAT), to the same level as the cold-exposed NR females. Serum leptin levels decreased significantly during lactation and were positively correlated with body mass and fat mass. After correcting for the effects of body mass, residual serum leptin was negatively correlated with residual gross energy intake and residual RMR. In addition, residual serum leptin levels were positively correlated with UCP1 contents in the warm, but not in the cold. Together, these data suggest that lactating voles can increase thermogenic capacity and energy intake to meet the high energetic costs of simultaneous lactation and cold exposure. Further, serum leptin appears to be involved in the energy intake regulation and thermoregulation, but the thermoregulation in the cold may be mainly mediated by other factors.