Stress T1-mapping cardiovascular magnetic resonance imaging and inducible myocardial ischemia
Stress T1-mapping cardiovascular magnetic resonance imaging and inducible myocardial ischemia
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DOI：
10.1007/s00392-019-01421-1
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发表时间：
2019-08-01
影响因子：
5
通讯作者：
Muellerleile, Kai
中科院分区：
文献类型：
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作者：
Bohnen, Sebastian;Pruessner, Lennard;Muellerleile, Kai
背景血管舒张应激下天然心肌T1的变化（“T1反应性”）最近被提出作为一种非造影剂心血管磁共振（CMR）方法来检测心肌缺血。本研究评估了一个节段性的，真正的非对比应力T1映射CMR的方法来检测诱导ischemia.Methods和结果的性能100例疑似/已知冠状动脉疾病进行CMR在3.0或1.5 T。在静息和regadenoson应激下使用5s（3s）3s-修改的look-locker反转-恢复（MOLLI）序列进行T1映射。我们将T1反应性定义为：（1）在16节段AHA模型中（独立于灌注图像）和（2）在从灌注图像复制到T1图的感兴趣局灶性区域中，从静息到应激的天然T1变化。我们比较了两种方法中可诱导缺血、瘢痕和远端心肌的节段/区域之间的T1反应性。与远端节段[2.49（95%CI，1.87至3.11）%; p < 0.01]相比，包括诱导性缺血的节段[-1.15（95%CI，-2.16至-0.14）%]的节段T1反应性显著降低。
Background Alterations in native myocardial T1 under vasodilation stress ("T1 reactivity") were recently proposed as a non-contrast cardiovascular magnetic resonance (CMR) method to detect myocardial ischemia. This study evaluated the performance of a segmental, truly non-contrast stress T1 mapping CMR approach to detect inducible ischemia.Methods and results One-hundred patients with suspected/known coronary artery disease underwent CMR at 3.0 or 1.5 T. T1 mapping was performed using the 5s(3s)3s-modified look-locker inversion-recovery (MOLLI) sequence at rest and under regadenoson stress. We defined T1 reactivity as the change in native T1 from rest to stress (1) in the 16-segment AHA model independent from perfusion images and (2) in focal regions of interest that were copied from perfusion images to T1 maps. We compared T1 reactivity between segments/regions with inducible ischemia, scar, and remote myocardium for both approaches. Segmental T1 reactivity was significantly lower in segments including inducible ischemia [-1.15 (95% CI, -2.16 to -0.14)%] compared to remote segments [2.49 (95% CI, 1.87 to 3.11)%; p