RESPONSE OF SERUM INTERLEUKIN-6 IN PATIENTS UNDERGOING ELECTIVE SURGERY OF VARYING SEVERITY
RESPONSE OF SERUM INTERLEUKIN-6 IN PATIENTS UNDERGOING ELECTIVE SURGERY OF VARYING SEVERITY
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DOI：
10.1042/cs0790161
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发表时间：
1990-08-01
期刊：
影响因子：
6
通讯作者：
SHENKIN, A
中科院分区：
文献类型：
--
作者：
CRUICKSHANK, AM;FRASER, WD;SHENKIN, A
1最近的研究表明白细胞介素-6（IL-6）是人类急性时相蛋白反应的主要介质，本研究旨在探讨血清IL-6对手术的反应、手术方式和血清C-反应蛋白反应之间的关系。2定时静脉血样本取自五大手术类别（小手术、胆囊切除术、髋关节置换术、结直肠手术和大血管手术）的26名患者。在每个样本中测量C-反应蛋白和白细胞介素-6。3.所有患者的血清白细胞介素-6在切口后2-4小时内升高，不同手术组的反应程度不同。白细胞介素-6的反应与手术时间相关（r = 0.80，P < 0.001）。相比之下，小手术（< 10 mg/l）后血清C-反应蛋白检测不到，并且C-反应蛋白的反应在较大手术组之间没有差异。IL-6与C-反应蛋白呈弱相关（r = 0.67，P < 0.001）。4.我们的结论是，血清白细胞介素-6是一个敏感的，组织损伤的早期标志物。一般来说，手术创伤越大，血清白细胞介素-6的反应越大，血清白细胞介素-6的峰值浓度越大。我们的研究结果是一致的白细胞介素-6在诱导C-反应蛋白合成的作用。
1 Recent studies have suggested that interleukin-6 is a major mediator of the acute-phase protein response in man. The aim of the present study was to investigate the relationships between the response of serum interleukin-6 to surgery, the type of surgical procedure performed and the response of serum C-reactive protein. 2 Timed venous blood samples were taken from 26 patients in five broad surgical categories (minor surgery, cholecystectomy, hip replacement, colorectal surgery and major vascular surgery). C-reactive protein and interleukin-6 were measured in each sample. 3. Serum interleukin-6 rose within 2-4 h of incision in all patients and the magnitude of the response differed among the various surgical groups. The response of interluekin-6 correlated (r = 0.80, P < 0.001) with the duration of surgery. In contrast, serum C-reactive protein was not detectable after minor surgery (< 10 mg/l) and the response of C-reactive protein did not differ among the more major surgical groups. The response of interleukin-6 showed a weak, but significant, correlation with the response of C-reactive protein (r = 0.67, P < 0.001). 4. We conclude that serum interleukin-6 is a sensitive, early marker of tissue damage. In general, the greater the surgical trauma, the greater the response of serum interleukin-6 and the greater the peak serum concentration of interleukin-6. Our results are consistent with a role of interleukin-6 in the induction of C-reactive protein synthesis.