Prospective association between major depressive disorder and leukocyte telomere length over two years.
Prospective association between major depressive disorder and leukocyte telomere length over two years.
复制标题
两年内重度抑郁症与白细胞端粒长度之间的前瞻性关联。
DOI：
10.1016/j.psyneuen.2018.02.015
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发表时间：
2018
影响因子：
3.7
通讯作者：
deVivo,Imma
中科院分区：
文献类型：
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作者：
Vance,MaryC;Bui,Eric;Hoeppner,SusanneS;Kovachy,Benjamin;Prescott,Jennifer;Mischoulon,David;Walton,ZandraE;Dong,Melissa;Nadal,MireyaF;Worthington,JohnJ;Hoge,ElizabethA;Cassano,Paolo;Orr,EstherH;Fava,Maurizio;deVivo,Imma
研究背景白细胞端粒长度（LTL）的减少与多种常见的年龄相关性疾病有关，包括心脏病、糖尿病和癌症。LTL缩短和重度抑郁症（MDD）之间也有联系，这表明MDD可能是一种加速衰老的疾病。这项前瞻性、纵向研究采用严格的入选标准，在一个良好表征的样本中，研究了基线时抑郁症诊断与两年内LTL变化之间的关系，样本为N = 117名基线时患有或不患有MDD的成年人，年龄在18-70岁的参与者在基线和两年随访时，由经过培训的医生级临床评估人员使用经验证的仪器进行评估。并在两次访视时采集血样。使用定量聚合酶链反应（qPCR）在相同方法下测定LTL。MDD的诊断在基线上的LTL的变化超过两年的效果进行了检查，通过分层混合模型，其中包括潜在的confers.ResultsIndividuals与MDD在基线上有更大的LTL缩短超过两年比没有MDD的人（p= 0.03），即使在控制年龄，性别和体重指数（BMI）的差异。在基线MDD诊断的个体子样本中，LTL变化和症状严重程度或持续时间之间没有显着关联被发现.ConclusionA基线MDD诊断前瞻性预测LTL缩短超过两年。我们的研究结果提供了进一步的支持，MDD作为一种疾病与加速老化在一个良好的表征样本使用验证，临床医生评定的措施。
BackgroundReduced leukocyte telomere length (LTL) has been found to be associated with multiple common age-related diseases, including heart disease, diabetes, and cancer. A link has also been suggested between shortened LTL and major depressive disorder (MDD), suggesting that MDD may be a disease of accelerated aging. This prospective, longitudinal study examined the association between depression diagnosis at baseline and change in LTL over two years in a well-characterized sample ofN= 117 adults with or without MDD at baseline, using rigorous entry criteria.MethodsParticipants aged 18–70 were assessed with validated instruments by trained, doctoral-level clinician raters at baseline and at two-year follow-up, and blood samples were obtained at both visits. LTL was assayed under identical methods using quantitative polymerase chain reaction (qPCR). The effect of an MDD diagnosis at baseline on change in LTL over two years was examined via hierarchical mixed models, which included potential confounders.ResultsIndividuals with MDD at baseline had greater LTL shortening over two years than individuals without MDD (p= 0.03), even after controlling for differences in age, sex, and body mass index (BMI). In the sub-sample of individuals with MDD diagnoses at baseline, no significant associations between LTL change and symptom severity or duration were found.ConclusionA baseline diagnosis of MDD prospectively predicted LTL shortening over two years. Our results provide further support for MDD as a disease associated with accelerated aging in a well-characterized sample using validated, clinician-rated measures.