Calcineurin regulation of cytoskeleton organization: a new paradigm to analyse the effects of calcineurin inhibitors on the kidney.
Calcineurin regulation of cytoskeleton organization: a new paradigm to analyse the effects of calcineurin inhibitors on the kidney.
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DOI：
10.1111/j.1582-4934.2011.01398.x
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发表时间：
2012-02
影响因子：
5.3
通讯作者：
Essig M
中科院分区：
文献类型：
--
作者：
Descazeaud V;Mestre E;Marquet P;Essig M
钙调神经磷酸酶是一种丝氨酸/苏氨酸磷酸酶，最初参与免疫应答，但也已知其在各种非免疫细胞内信号中作为中心介体的作用。活化T细胞核因子（NFAT）蛋白是钙调磷酸酶最广泛描述的底物，但正在进行的工作已经发现了其他底物，其中包括细胞骨架组织蛋白（即cofilin、synaptopodin、WAVE-1）。控制细胞骨架蛋白是最感兴趣的，因为细胞的表型特性取决于细胞骨架结构的完整性，而细胞骨架的重排涉及生理和病理过程。以往的研究主要集中在神经突起的延伸、肌细胞的肥大反应以及最近在肾脏细胞结构中的作用。活化T细胞活化的核因子在钙调神经磷酸酶诱导的细胞骨架组织的信号通路中被初步鉴定，然而新的NFAT非依赖性通路也被发现。本文综述了钙调神经磷酸酶对细胞骨架蛋白及相关细胞内通路的影响。这些新描述的钙调磷酸酶对细胞骨架蛋白的特性可以解释与使用钙调磷酸酶抑制剂，环孢素和他克莫司相关的肾细胞中观察到的一些有益或有害的影响。
Calcineurin is a serine/threonine phosphatase originally involved in the immune response but is also known for its role as a central mediator in various non-immunological intracellular signals. The nuclear factor of activated T cell (NFAT) proteins are the most widely described substrates of calcineurin, but ongoing work has uncovered other substrates among which are the cytoskeleton organizing proteins (i.e. cofilin, synaptopodin, WAVE-1). Control over cytoskeletal proteins is of outmost interest because the phenotypic properties of cells are dependent on cytoskeleton architecture integrity, while rearrangements of the cytoskeleton are implicated in both physiological and pathological processes. Previous works investigating the role of calcineurin on the cytoskeleton have focused on neurite elongation, myocyte hypertrophic response and recently in kidney cells structure. Nuclear factor of activated T cell activation is expectedly identified in the signalling pathways for calcineurin-induced cytoskeleton organization, however new NFAT-independent pathways have also been uncovered. The aim of this review is to summarize the current knowledge on the effects of calcineurin on cytoskeletal proteins and related intracellular pathways. These newly described properties of calcineurin on cytoskeletal proteins may explain some of the beneficial or deleterious effects observed in kidney cells associated with the use of the calcineurin inhibitors, cyclosporine and tacrolimus.
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DOI：
10.1073/pnas.072647999
发表时间：
2002-04-02
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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通讯作者：
Force, T