Ghrelin and memory: Differential effects on acquisition and retrieval
Ghrelin and memory: Differential effects on acquisition and retrieval
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DOI：
10.1016/j.peptides.2010.02.021
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发表时间：
2010-06-01
期刊：
影响因子：
3
通讯作者：
de Barioglio, Susana R.
中科院分区：
文献类型：
--
作者：
Carlini, Valeria P.;Ghersi, Marisa;de Barioglio, Susana R.
在之前的论文中，我们已经证明了食欲肽Ghrelin（Ghr）可以增加大鼠和小鼠的记忆力。在本工作中，我们评估了Ghr的效果时，它被管理之前的培训会议或之前的测试会议（培训后24小时）的记忆性能，使用降压测试。结果表明，在训练前给予海马内Ghr可改善该任务的长时记忆，但不改变短时记忆。然而，当在测试阶段之前施用Ghr时，未观察到记忆性能的变化。考虑到这些结果和其他先前发表的我们的小组，我们可以假设，GHR可能会调节特定的分子中间体参与记忆的获取/巩固，但不是在检索。(C)2010年爱思唯尔公司All rights reserved.
In a previous paper we have demonstrated that the orexigenic peptide Ghrelin (Ghr), increases memory retention in rats and mice. In the present work we evaluated the Ghr effect when it was administered previous the training session or previous the test session (24 h after training) on the memory performance, using step-down test. The results showed that the intra-hippocampal Ghr administration previous the training session improved the long-term memory in this task, but did not modify the short-term memory. Nevertheless, when the Ghr was administrated previous the test session, no changes were observed in the memory performance. Taking into account these results and other previously published by our group, we could hypothesizes that Ghr may modulate specific molecular intermediates involved in memory acquisition/consolidation but not in the retrieval. (C) 2010 Elsevier Inc. All rights reserved.