Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats
Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats
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DOI：
10.1037//1064-1297.9.3.251
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发表时间：
2001-08-01
影响因子：
2.3
通讯作者：
Klein, LC
中科院分区：
文献类型：
--
作者：
Klein, LC
在成年大鼠中研究了青少年尼古丁暴露对非法药物消费和神经内分泌功能的影响。尼古丁（NIC; 2剂）或生理盐水（SAL）通过渗透微泵给予30只雄性和30只雌性青春期Wistar大鼠19天。在NIC/SAL停止后，在饲养笼中评估口服阿片类药物消耗4周。实验结束时测定血浆皮质酮和促肾上腺皮质激素。低NIC雄性大鼠消耗更多的芬太尼比高NIC雄性大鼠;阿片类药物的消耗在成年雌性大鼠中不改变NIC曝光。女性比男性消耗更多的芬太尼，无论NIC的历史。NIC暴露以剂量依赖性方式增加成人皮质酮和ACTH水平。结果表明，青少年NIC暴露的重要影响，包括改变神经内分泌状态和阿片类药物的消费。
Effects of adolescent nicotine exposure on illicit drug consumption and neuroendocrine functioning were examined in adult rats. Nicotine (NIC; 2 doses) or saline (SAL) was administered via osmotic minipumps to 30 male and 30 female adolescent Wistar rats for 19 days. After NIC/SAL cessation, oral opioid consumption was assessed in the home cage for 4 weeks. Plasma corticosterone and ACTH were measured at the end of the experiment. Low-NIC male rats consumed more fentanyl than did high-NIC male rats; opioid consumption among adult female rats was not altered by NIC exposure. Females consumed more fentanyl than did males, regardless of NIC history. NIC exposure increased adult corticosterone and ACTH levels in a dose-dependent manner. Results suggest important effects of adolescent NIC exposure, including altered neuroendocrine status and opioid consumption.