Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects
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DOI：
10.1172/jci118551
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发表时间：
1996-03-01
影响因子：
15.9
通讯作者：
Caro, JF
中科院分区：
文献类型：
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作者：
Sinha, MK;Ohannesian, JP;Caro, JF
我们研究了在正常日常活动期间，使用敏感和特异性RZA在瘦对照组和肥胖受试者（有或无非胰岛素依赖型糖尿病（NIDDM））中循环瘦素水平的24小时曲线。肥胖（41.7 ± 9.0 ng/ml; n = 11）和肥胖NIDDM（30.8 ± 6.7; n = 9）受试者的血清瘦素水平显著高于瘦对照组（12.0 ± 4.4，n = 6）。在所有三组中，血清瘦素水平在午夜和清晨之间最高，中午到下午三点左右最低。通过方差分析，夜间瘦素水平的升高是显著的（瘦型：F = 3.17，P < 0.0001，n = 4;肥胖型：F = 2.02，P < 0.005，n = 11;肥胖型NIDDM：峰值相与最低值之间的平均昼夜振幅在瘦型、肥胖型和肥胖型NIDDM组分别为75.6%、51.7%和60.7%。20名受试者的24小时血瘦素水平与胰岛素或葡萄糖水平均无显著相关性（P > 0.05）。本研究中观察到的瘦素夜间升高与催乳素、促甲状腺激素和游离脂肪酸的升高相似。我们推测，夜间瘦素的升高可能会在夜间睡眠时抑制食欲。
We studied 24-h profiles of circulating leptin levels using a sensitive and specific RZA in lean controls and obese subjects with or without non-insulin-dependent diabetes mellitus (NIDDM) during normal routine activity. Serum leptin levels were significantly higher in obese (41.7+/-9.0 ng/ml; n = 11) and obese NIDDM (30.8+/-6.7; n = 9) subjects compared with those in lean controls (12.0+4.4, n = 6). In all the three groups, serum leptin levels were highest between midnight and early morning hours and lowest around noon to midafternoon. The nocturnal rise in leptin levels was significant when data were analyzed by ANOVA (lean: F = 3.17, P < 0.0001, n = 4; obese: F = 2.02, P < 0.005, n = 11; and obese NIDDM: F = 4.9, P < 0.0001, n = 5), The average circadian amplitude between acrophase and nadir was 75.6% in lean, 51.7%, in obese and 60.7% in obese NIDDM groups, respectively. No significant correlations (P > 0.05) were observed between circulating levels of leptin and either insulin or glucose levels in any of the 20 subjects studied for 24-h profiles. The nocturnal rise in leptin observed in the present study resembles those reported for prolactin, thyroid-stimulating hormone, and free fatty acids. We speculate that the nocturnal rise in leptin could have an effect in suppressing appetite during the night while sleeping.