Short-term follow-up of intestinal flora in radiation-exposed mice
Short-term follow-up of intestinal flora in radiation-exposed mice
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DOI：
10.1093/jrr/rrz002
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发表时间：
2019-04
影响因子：
2
通讯作者：
K. Yamanouchi;T. Tsujiguchi;Yamato Sakamoto;Koichi Ito
中科院分区：
文献类型：
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作者：
K. Yamanouchi;T. Tsujiguchi;Yamato Sakamoto;Koichi Ito
摘要 一些胃肠道细菌，也称为“肠道菌群”，可引起严重的胃肠道问题，包括败血症，这与包括心血管疾病在内的生活方式相关疾病密切相关。一些研究的重点是与辐射暴露相关的肠道菌群的长期变化。然而，短期影响仍未知。在这项研究中，我们追踪了暴露于不同剂量X射线照射（2 Gy和4 Gy）的小鼠肠道菌群的短期变化，仅关注乳酸菌双歧杆菌和乳杆菌。在暴露于 2 Gy 和 4 Gy 辐射的个体中，在辐射后立即检测到乳酸菌丰度下降。然而，暴露于 4 Gy 辐射的小鼠中双歧杆菌显着增加，表明这些细菌在肠上皮组织再生中具有潜在作用。关于辐射暴露导致肠道细菌变化的研究有限。因此，这一领域的研究的继续有望为辐射对肠道组织造成损伤、导致脓毒症发生的机制提供重要的基础见解。
Abstract Some gastrointestinal bacteria, otherwise known as the ‘intestinal flora’, can cause severe gastrointestinal problems, including sepsis, which are strongly linked to lifestyle-related diseases, including cardiovascular diseases. Several investigations have focused on the long-term changes in the intestinal flora associated with radiation exposure; however, the short-term effects remain unknown. In this study, we tracked the short-term changes in the intestinal flora of mice exposed to different doses of X-ray irradiation (2 Gy and 4 Gy), focusing only on the lactic acid bacteria Bifidobacterium and Lactobacillus. A decrease in the Lactobacillus abundance was detected immediately after irradiation in individuals exposed to both 2 Gy and 4 Gy irradiation. However, mice exposed to 4 Gy of irradiation showed a remarkable increase in Bifidobacterium, indicating a potential role of these bacteria in regeneration of the intestinal epithelial tissue. Studies on changes in intestinal bacteria as a result of radiation exposure are limited. Therefore, continuation of this field of research is expected to provide important fundamental insight into the mechanisms by which radiation causes damage to the intestinal tissues, contributing to the development of sepsis.