Cytokines pattern after surgical radiofrequency ablation of liver colorectal metastases
Cytokines pattern after surgical radiofrequency ablation of liver colorectal metastases
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DOI：
10.1016/s0399-8320(07)89344-4
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发表时间：
2007-02-01
影响因子：
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通讯作者：
Rosenbaum, Jean
中科院分区：
文献类型：
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作者：
Evrard, Serge;Menetrier-Crux, Christine;Rosenbaum, Jean
目的-本研究的目的是评估手术射频消融（SRFA）后结肠直肠癌转移灶的血清细胞因子演变模式。方法：10例非连续患者的转移灶在完整的手术程序（包括剖腹手术、腹膜检查、肝脏动员和肝脏超声检查）后，通过射频消融术摧毁，而没有同时切除。ELISA法检测不同时间点血清IL-6、TNF α、HGF、VEGF、bFGF、TGF β 1、CRP水平。结果- TNF α和bFGF仍未检测到。IL-6在3小时达到峰值，并在整个研究期间保持升高。HGF在第1天增加3倍，然后下降，直到第7天仍然是基线水平的两倍。VEGF水平从第5天开始升高。TGF β 1无明显变化。CRP在整个研究过程中升高。结论：与冷冻治疗相比，SRFA不会导致高血清TNF α，这表明其耐受性更好。然而，高IL-6， HGF和VEGF的血清水平是一般炎症应激的特征，这应该被考虑在内。
Aims - The aim of this study was to evaluate the serum pattern of cytokines evolution after surgical radiofrequency ablation (SRFA) of colorectal metastases.Methods - Metastases of ten non consecutive patients were destroyed by radiofrequency ablation without concomitant resection after a complete surgical procedure including a laparotomy, a peritoneal examination, liver mobilisation and liver ultrasound. Serum levels of IL-6, TNF alpha, HGF, VEGF, bFGF, TGF beta 1 and CRP were assessed by ELISA assays at different time points.Results - TNF alpha and bFGF remained undetectable. IL-6 peaked at 3 hours and remained elevated during the entire study period. HGF increased by three-fold by Day 1 then decreased until Day 7 where it was still twice its baseline level. VEGF level increased from Day 5 onward. TGF beta 1 did not show significant variations. CRP was increased throughout the study.Conclusions - In contrast with cryotherapy, SRFA does not lead to high serum TNF alpha suggesting a better tolerance. Nevertheless high IL-6, HGF and VEGF serum levels are characteristic of a general inflammatory stress which should be taken into account.