Determination of prognosis in patients with prostate cancer treated with radical prostatectomy:: Prognostic value of CD44v6 score
Determination of prognosis in patients with prostate cancer treated with radical prostatectomy:: Prognostic value of CD44v6 score
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DOI：
10.1016/s0022-5347(05)65078-1
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发表时间：
2002-05-01
影响因子：
6.6
通讯作者：
Özen, H
中科院分区：
文献类型：
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作者：
Ekici, S;Ayhan, A;Özen, H
目的：三分之一接受根治性前列腺切除术的患者即使肿瘤病理上局限于前列腺，也会出现进展。CD 44可能是判断恶性潜能的一个有前途的预后标志物。然而，由于其染色模式的异质性，一直没有一个标准的评分系统。因此，我们开发了一个客观的评分系统，以评估可靠的CD 44 v6（Bender Medsystems，维也纳，奥地利）作为前列腺癌的预后标志物。材料和方法：共22例转移性阶段pT 3bN 0 M0或任何pTN 1 M0疾病和18个非转移性疾病小于阶段pT 3bN 0 M0的114人接受根治性耻骨后前列腺切除术检查组。平均随访33个月（范围4 - 78）。通过将主要区域和次要区域的评分相加来确定组合的CD 44 v6评分。根据原发性和转移性组织中的CD 44 v6评分检查CD 44 v6表达。同时分析CD 44 v6表达与肿瘤分期、进展及无PSA生存期的关系。结果：转移组的进展率显著高于非转移组（P < 0. 05），转移组的进展率显著高于非转移组（P < 0. 05），转移组的进展率显著高于非转移组（P < 0. 05），转移组的进展率显著高于非转移组（P < 0. 05）。
Purpose: A third of the patients treated with radical prostatectomy experience progression even when tumors are confined pathologically to the prostate. CD44 may be a promising prognostic marker for determining malignant potential. However, there has not been a standard scoring system because of its heterogeneous staining pattern. Thus, we developed an objective scoring system to evaluate reliably CD44v6 (Bender Medsystems, Vienna, Austria) as a prognostic marker for prostate cancer.Materials and Methods: A total of 22 patients with metastatic stage pT3bN0M0 or any pTN1M0 disease and 18 with nonmetastatic disease less than stage pT3bN0M0 were selected from a well examined group of 114 who underwent radical retropubic prostatectomy. Mean followup was 33 months (range 4 to 78). A combined CD44v6 score was determined by adding the scores of the primary and secondary areas. CD44v6 expression in terms of the CD44v6 score in primary and metastatic tissues was examined. The relationships of CD44v6 expression with pathological stage, progression and PSA-free survival were also evaluated. The prognostic value of the CD44v6 score for progression was analyzed by multivariate analysis.Results: Progression in the metastatic group was significantly higher than in the nonmetastatic group (p