Photopolymerized check valve and its integration into a pneumatic pumping system for biocompatible sample delivery
Photopolymerized check valve and its integration into a pneumatic pumping system for biocompatible sample delivery
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DOI：
10.1039/b606918e
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发表时间：
2006-01-01
期刊：
影响因子：
6.1
通讯作者：
Lee, SangHoon
中科院分区：
文献类型：
--
作者：
Kim, JeongYun;Baek, JuYeoul;Lee, SangHoon
在本文中，我们提出了一个简单的止回阀，其操作模仿静脉阀。我们的止回阀具有单叶结构，并通过PDMS平台内部的原位制造方法构建。阀瓣的弹性和形状以及阀瓣与通道表面之间的润滑对阀瓣的顺利工作至关重要。我们使用4-羟丙烯酸丁酯（4-HBA）作为弹性和光聚合的小叶材料。我们将triton X-100与4-HBA预聚合物溶液混合，以充分润滑传单。我们将两个类静脉止回阀与一个由气动驱动的振荡聚合物隔膜组合在一起，构建了微泵系统，并根据泵送频率的变化测量了流量。我们还利用小鼠胚胎成纤维细胞研究了该泵作为生物相容性材料输送系统的可行性。
In this paper, we present a simple check valve whose operation mimics that of venous valves. Our check valve has a mono-leaflet and is constructed via an in situ fabrication method inside the PDMS platform. For the smooth operation of the valve's leaflet, the elasticity and the shape of the leaflet and the lubrication between the leaflet and the channel surface are important. We used 4-hydroxybutyl acrylate (4-HBA) as an elastic and photopolymerizable leaflet material. We mixed the triton X-100 with the 4-HBA pre-polymer solution for the adequate lubrication of the leaflet. We constructed the micro-pumping system by combining two venous-like check valves with an oscillating polymeric diaphragm driven by pneumatic force, and measured the flow rate according to the change of pumping frequency. We also investigated the pump's feasibility as a delivery system of biocompatible materials by using mouse embryo fibroblast cells.