3D printed tetrakis(triphenylphosphine)palladium (0) impregnated stirrer devices for Suzuki-Miyaura cross-coupling reactions
3D printed tetrakis(triphenylphosphine)palladium (0) impregnated stirrer devices for Suzuki-Miyaura cross-coupling reactions
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DOI：
10.1039/d2re00218c
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发表时间：
2022-09-06
影响因子：
3.9
通讯作者：
Hilton, Stephen T. T.
中科院分区：
文献类型：
--
作者：
Penny, Matthew R. R.;Rao, Zenobia X. X.;Hilton, Stephen T. T.
3D打印材料可以很容易地进行修改，以创建在打印时包含一系列催化剂的定制结构。在本研究中，我们报告了四（三苯基膦）钯（0）浸渍的3D打印搅拌器装置的设计和3D打印，该搅拌器装置用于以基于批处理的方法催化联芳基化合物之间的Suzuki-Miyaura反应。结果表明，3D打印设备本身对溶剂稳定，可重复使用，易于使用，空气稳定，以优异的产率获得一系列联芳基化合物，并导致反应中的钯损失水平较低。通过减小尺寸对装置的设计进行简单的修改，意味着它们也可以用于通过微波增强加热来减少铃木-宫浦反应的时间。在反应结束时，装置可以简单地从烧瓶中取出，清洗并重复使用，类似于搅拌珠的工作流程。这使得建立多个反应的整个过程更简单，因为不需要称量用于反应的催化剂，并且一旦使用，可以在反应结束时简单地从反应介质中移除装置。
3D printed materials can be readily modified to create bespoke structures that incorporate a range of catalysts at the point of printing. In this present study we report on the design and 3D printing of tetrakis (triphenylphosphine) palladium (0) impregnated 3D printed stirrer devices that were used to catalyze a Suzuki-Miyaura reaction between biaryl compounds in a batch-based approach. It was shown that the 3D printed devices themselves are stable to solvent, reusable, easy to use, air-stable, give access to an array of biaryl compounds in excellent yields and lead to low levels of palladium loss into the reaction. Simple modification of the device's design by size reduction, meant that they could also be used to reduce the time of the Suzuki-Miyaura reaction by microwave enhanced heating. At the end of the reaction, devices can simply be removed from the flask, washed and reused, analogous to stirrer bead workflows. This makes the overall process of setting up multiple reactions simpler by obviating the need to weigh out catalysts for reactions and the device, once used, can be simply removed from the reaction media at the end of the reaction.