Sex-dependent gene expression and evolution of the Drosophila transcriptome
Sex-dependent gene expression and evolution of the Drosophila transcriptome
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DOI：
10.1126/science.1085881
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发表时间：
2003-06-13
期刊：
影响因子：
56.9
通讯作者：
Hartl, DL
中科院分区：
文献类型：
--
作者：
Ranz, JM;Castillo-Davis, CI;Hartl, DL
黑腹果蝇和模拟果蝇成虫之间基因表达谱的比较揭示了表现出性别依赖性调节的基因的进化。大约一半的基因在物种之间表现出表达差异，其中大约 83% 涉及性别偏向表达的获得、损失、增加、减少或逆转。信使 RNA 丰度的大多数种间差异都会影响偏雄性的基因。物种之间表达不同的基因只有在具有性别偏见时才显示出功能聚类。我们的结果表明，性别依赖性选择可能会驱动果蝇转录组中许多进化最快的基因表达的变化。
Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, similar to83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.