Surface markers of complement receptor lymphocytes.
Surface markers of complement receptor lymphocytes.
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补体受体淋巴细胞的表面标记。
DOI：
10.1172/jci109214
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
T. Hoffman
中科院分区：
文献类型：
--
作者：
G. D. Ross;R. Winchester;E. Rabellino;T. Hoffman
携带补体受体 (CRL) 的正常血液淋巴细胞分为两个群体，一组同时表达 CR1（C4b-C3b 受体）和 CR2（C3d 受体），另一组仅表达 CR1。几乎所有同时表达 CR1 和 CR2 的群体也携带膜表面免疫球蛋白 (Ig) 和 Ia 抗原。大多数仅具有 CR1 的细胞缺乏可检测的表面 Ig。这些 Ig-CR1+ CR2- 细胞可以与大多数单核细胞和未成熟粒细胞区分开来，因为后者摄入乳胶颗粒并表达 CR2 和 CR1。 Ig-CR1+ 细胞进一步细分为携带 Ia 的亚群和缺乏 Ia 的亚群。在 Ig-Ia-CR1+ 细胞中，三分之一与绵羊红细胞自发形成玫瑰花结，而所有剩余的 CRL 均为红细胞玫瑰花结阴性。基本上正常血液中的所有 CRL 都具有 IgG Fc 受体，但在 Ia+ CRL 与 Ia- CRL 的 Fc 受体与不同免疫复合物系统的结合方面观察到了定性异质性。
Normal blood lymphocytes bearing complement receptors (CRL) were divided into two populations, one expressing both CR1 (C4b-C3b receptor) and CR2 (C3d receptor) and a second expressing only CR1. Nearly all of the population that expressed both CR1 and CR2 also bore membrane surface immunoglobulins (Ig) and Ia antigens. The majority of cells that had only CR1 lacked detectable surface Ig. These Ig- CR1+ CR2- cells could be distinguished from the majority of monocytes and immature granulocytes, in that the latter ingested latex particles and expressed CR2 as well as CR1. The Ig- CR1+ cells were further subdivided into an Ia-bearing subpopulation and another that lacked Ia. Among the Ig- Ia- CR1+ cells, one third formed spontaneous rosettes with sheep erythrocytes while all of the remaining CRL were erythrocyte-rosette negative. Essentially all CRL in normal blood had IgG Fc receptors, but a qualitative heterogeneity in the Fc receptors of Ia+ CRL vs. Ia- CRL was observed in their binding of different immune complex systems.