Potential of continuous tPA infusion for MOF from lipopolysaccharide-induced disseminated intravascular coagulation in rats

Potential of continuous tPA infusion for MOF from lipopolysaccharide-induced disseminated intravascular coagulation in rats
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连续 tPA 输注治疗脂多糖诱导的大鼠弥散性血管内凝血 MOF 的潜力

DOI:
10.1016/j.thromres.2021.08.014
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发表时间:
2021
期刊:
影响因子:
7.5
通讯作者:
Asakura H
Asakura H
中科院分区:
医学3区
文献类型:
--
作者:
Suga Y;Tashiro K;Staub Y;Komura S;Yamada S;Morishita E;Asakura H

文献摘要

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TPA可抑制DIC大鼠的血小板减少,肾功能障碍在内毒素+tPA组较内毒素组明显减轻。
HighlightstPA could show the improvement effect on organ failure.Thrombocytopenia in DIC was suppressed by tPA administration.Renal dysfunction was lower in the LPS+ tPA group than in the LPS group.