Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
复制标题
DOI：
10.1023/a:1006868409841
复制
发表时间：
1998-05-01
影响因子：
4.3
通讯作者：
Kusari, J
中科院分区：
文献类型：
--
作者：
Byon, JCH;Kusari, AB;Kusari, J
胰岛素信号转导涉及蛋白质酪氨酸磷酸化和去磷酸化的动态级联。我们对这一过程的理解大多来自于对酪氨酸激酶的研究，酪氨酸激酶是信号激活剂。我们对蛋白酪氨酸磷酸酶（PTPases），信号衰减剂，在调节胰岛素信号转导中的作用的认识仍然相当有限。蛋白酪氨酸磷酸酶1B（PTP-1B）是一种典型的酪氨酸磷酸酶，广泛表达。包括我们自己的实验室在内的几个实验室的工作表明，PTP-1B是胰岛素作用的负调节剂，也是胰岛素抵抗和非胰岛素依赖型糖尿病（NIDDM）发病机制中潜在的重要介质。
Insulin signaling involves a dynamic cascade of protein tyrosine phosphorylation and dephosphorylation. Most of our understanding of this process comes from studies focusing on tyrosine kinases, which are signal activators. Our knowledge of the role of protein-tyrosine phosphatases (PTPases), signal attenuators, in regulating insulin signal transduction remains rather limited. Protein-tyrosine phosphatase 1B (PTP-1B), the prototypical PTPase, is ubiquitously and abundantly expressed. Work from several laboratories, including our own, has implicated PTP-1B as a negative regulator of insulin action and as a potentially important mediator in the pathogenesis of insulin-resistance and non-insulin dependent diabetes mellitus (NIDDM).