The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly
The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly
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DOI：
10.1016/j.vaccine.2010.04.103
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发表时间：
2010-07-05
期刊：
影响因子：
5.5
通讯作者：
Goldblatt, David
中科院分区：
文献类型：
--
作者：
Baxendale, Helen E.;Keating, Sheila M.;Goldblatt, David
在幼儿中，多价肺炎球菌多糖结合疫苗(PCV)在免疫原性和启动记忆反应方面都比普通多糖疫苗(PPV)具有优势。在老年人中，结合疫苗的潜在益处尚不清楚。在这里，我们探索了PPV疫苗、Pappovax(TM)或PCV：Prevenar(TM)免疫老年人(n=37)对肺炎球菌荚膜多糖(PPS)的血清抗体、循环血浆和记忆B细胞反应的早期动力学。所有个体都有血清证据表明先前存在血清型特异性免疫。免疫后，两个疫苗组循环中的PPS特异性血浆和记忆抗体分泌细胞(AbSCs)在第7天都检测到上升，并且在一些PCV接受者中持续到第28天。在血清抗体反应或早期PBMC来源的B细胞反应的动力学方面，疫苗组之间没有差异。尽管我们的样本队列很小，但这些数据与免疫后早期年轻人的情况不同，表明肺炎球菌结合疫苗可能不会定量地增强老年人记忆反应的产生。(C)2010爱思唯尔有限公司。保留所有权利。
In young children, polyvalent pneumococcal polysaccharide conjugate vaccines (PCVs) have been shown to offer advantage over plain polysaccharide vaccines (PPVs) in both immunogenicity and priming for memory responses. In the elderly, the potential benefit of conjugate vaccines is unclear.Here, we explore the early kinetics of serum antibody and circulating plasma and memory B cell responses to pneumococcal capsular polysaccharide (PPS) in older adults (n = 37) immunised a PPV vaccine, Pneumovax (TM) or a PCV: Prevenar (TM). All individuals had serum evidence of pre-existing serotype-specific immunity. Following immunisation, a day 7 rise in circulating PPS-specific plasma and memory antibody secreting cells (AbSCs) was detected in both vaccine groups and this was sustained to day 28 in some PCV recipients. There was no difference between vaccine groups in serum antibody responses or the kinetics of the early PBMC-derived B cell responses. Although our sample cohort was small, these data are different from profiles in younger individuals at early time points post-immunisation and suggest that pneumococcal conjugate vaccines may not quantitatively enhance the generation of memory responses in the elderly. (C) 2010 Elsevier Ltd. All rights reserved.