Fasting remnant lipoproteins can predict postprandial hyperlipidemia.
Fasting remnant lipoproteins can predict postprandial hyperlipidemia.
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DOI：
10.1186/1476-511x-11-146
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发表时间：
2012-10-31
影响因子：
4.5
通讯作者：
Fujioka Y
中科院分区：
文献类型：
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作者：
Nagata T;Sugiyama D;Kise T;Tsuji S;Ohira H;Sato I;Yamamoto M;Kohsaka H;Kawano S;Yamashita S;Ishikawa Y;Fujioka Y
高甘油三酯血症和餐后高脂血症被认为在动脉粥样硬化中起重要作用，但在这些患者中仅用甘油三酯（TG）难以选择心血管疾病的高危患者。为了预测餐后高脂血症，而不方便测试餐负荷，我们检查了测试餐负荷和空腹脂联素之前和之后的脂质浓度，并调查了45名健康个体（男性：女性，26：19）在空腹期间除TG之外的其他血脂水平。TG、残粒样胆固醇和甘油三酯（RemL-C、RLP-C和RLP-TG）以及TG/载脂蛋白（apo）B在负荷后和空腹值显著升高，并与曲线下面积（iAUC）增量显著正相关（r=0.80、r=0.79、r=0.63、r=0.58、r=0.54; p<0.0001）。空腹脂联素与空腹高密度脂蛋白胆固醇（r=0.43，p<0.005）和apoA-I（r=0.34，p<0.05）呈正相关，与TG、RemL-C、RLP-C、RLP-TG和TG/apoB的iAUC呈负相关（r=-0.37，r=-0.41，r=-0.37，r=-0.36，r=-0.37; p<0.05）。在不考虑空腹TG的情况下，建立多因素线性回归分析模型。在所有参与者中，在测试餐负荷后2小时餐后TG升高的性别，BMI，年龄和腰围调整分析中，RemL-C，RLP-C，RLP-TG和TG/apoB是显著因素，但脂联素不是。空腹富胆固醇脂蛋白相关值，尤其是RemL-C、RLP-C、RLP-TG和TG/apoB是年轻健康个体餐后高脂血症的有用预测因子。虽然空腹脂联素浓度与TG、RemL-C、RLP-C、RLP-TG和TG/apoB的iAUC相关，但在多变量线性回归分析中，它不是餐后高脂血症的显著预测因子。
Hypertriglyceridemia and postprandial hyperlipidemia is thought to play an important role in atherosclerosis, but to select patients at high-risk for cardiovascular diseases is difficult with triglycerides (TG) alone in these patients. To predict postprandial hyperlipidemia without inconvenient test meal loading, we examined lipid concentrations before and after test meal loading and fasting adiponectin, and investigated which of these other than TG were significant during the fasting period in 45 healthy individuals (men: women, 26:19). TG, remnant-like particle-cholesterol and -triglyceride (RemL-C, RLP-C, and RLP-TG), and TG/apolipoprotein(apo)B were significantly elevated after loading and fasting values significantly and positively correlated with incremental area under the curve (iAUC) (r=0.80, r=0.79, r=0.63, r=0.58, r=0.54; p<0.0001). Fasting adiponectin positively correlated with fasting high-density lipoprotein-cholesterol (r=0.43, p<0.005) and apoA-I (r=0.34, p<0.05), and negatively correlated with iAUC of TG, RemL-C, RLP-C, RLP-TG, and TG/apoB (r=−0.37, r=−0.41, r=−0.37, r=−0.36, r=−0.37; p<0.05). We constructed the model of multivariable linear regression analysis without fasting TG. In the sex-, BMI-, age-, and waist circumference-adjusted analysis of postprandial TG elevation 2 h after test meal loading in all participants, RemL-C, RLP-C, RLP-TG, and TG/apoB were significant factors, but adiponectin was not. Fasting triglyceride-rich lipoprotein-related values, especially RemL-C, RLP-C, RLP-TG, and TG/apoB are useful predictors of postprandial hyperlipidemia in young healthy individuals. Although fasting adiponectin concentration correlated with the iAUCs for TG, RemL-C, RLP-C, RLP-TG, and TG/apoB, it was not a significant predictor of postprandial hyperlipidemia in multivariable linear regression analysis.