Cyclic Ether-Containing Macrolactins, Antimicrobial 24-Membered Isomeric Macrolactones from a Marine Bacillus sp.
Cyclic Ether-Containing Macrolactins, Antimicrobial 24-Membered Isomeric Macrolactones from a Marine Bacillus sp.
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DOI：
10.1021/np200487k
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发表时间：
2011-12-01
影响因子：
5.1
通讯作者：
Shin, Hee Jae
中科院分区：
文献类型：
--
作者：
Mondol, M. A. Mojid;Tareq, Fakir Shahidullah;Shin, Hee Jae
从海洋芽孢杆菌发酵液的乙酸乙酯提取物中分离生物活性代谢物，发现了三个新的24元大内酯，大内酯1-3，它们分别含有一个氧烷、一个环氧化物和一个四氢吡喃环。结合耦合常数、ROESY数据分析和改进的Mosher方法对1-3的构型进行赋值。化合物1 ~ 3具有体外抑菌活性。
Bioassay-guided isolation of bioactive metabolites from the ethyl acetate extract of a marine Bacillus sp. fermentation broth has led to the discovery of three new 24-membered macrolactones, macrolactins 1-3, which contain an oxetane, an epoxide, and a tetrahydropyran ring, respectively. The configurations of 1-3 were assigned by a combination of coupling constants, ROESY data analysis, and application of the modified Mosher's method. Compounds 1-3 showed in vitro antimicrobial activity.