Elevated Levels of Plasmin-α2 Antiplasmin Complexes in Unstable Angina
Elevated Levels of Plasmin-α2 Antiplasmin Complexes in Unstable Angina
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不稳定型心绞痛中纤溶酶-α2 抗纤溶酶复合物水平升高
DOI：
10.1055/s-0037-1614589
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发表时间：
1999
影响因子：
6.7
通讯作者：
A. Bayés de Luna
中科院分区：
文献类型：
--
作者：
A. Bayés‐Genís;J. Guindo;A. Oliver;L. Badimón;M. Fiol;J. Mateo;Joan Carles Souto;J. Dominguez;J. Fontcuberta;A. Bayés de Luna
结论：不稳定型心绞痛患者血栓前状态的几个生化标志物水平升高的证据表明，血栓形成和溶解在急性冠脉综合征中起着关键作用。不稳定型心绞痛的临床综合征包括一过性心肌缺血发作的各种临床表现。这项研究旨在评估不同情况下不稳定型心绞痛的纤溶酶生成。用循环纤溶酶-α-2抗纤溶酶复合体检测不稳定型心绞痛患者纤溶酶生成的证据。第二个目标是确定PAP水平是否具有预测预后的价值。85名因不稳定型心绞痛而住进冠状动脉监护病房的患者被分成三组。A组26例为梗塞后心绞痛；B组26例为新发心绞痛；C组33例为新月型心绞痛。与健康对照组相比，三组的平均PAP水平更高。PAP和D-二聚体水平之间存在显著的相关性，尤其是在梗塞后心绞痛(r=0.60；p<；0.0005)。这项试验为不稳定性心绞痛的病理生理学增加了新的见解。研究表明，纤溶酶在不同情况下的不稳定心绞痛中产生，尤其是在梗死后心绞痛患者中，富含纤维蛋白的血栓是导致症状的原因。然而，在本系列中，无论是在急性期还是在长期(6个月)，PAP水平都不能预测无事件的结果。缩写和首字母缩写：CABG：冠状动脉搭桥术；CCU：冠状动脉监护病房；ECG：心电图；IABP：主动脉内球囊反搏；MI：心肌梗死；PAP：纤溶酶-α-2抗纤溶酶复合体；PTCA：经皮腔内冠状动脉成形术
Summary The evidence of elevated levels of several biochemical markers of prothrombotic state in patients with unstable angina suggests that thrombus formation and lysis play a pivotal role in acute coronary syndromes. The clinical syndrome of unstable angina encompasses a variety of clinical presentations of transient episodes of myocardial ischemia. This study was designed to assess plasmin generation in different settings of unstable angina. Evidence of plasmin generation in patients with unstable angina was measured by circulating plasmin-α2 antiplas-min complexes (PAP). A second objective was to identify whether PAP levels had a prognostic value to predict outcome. Eighty-five patients admitted to the coronary care unit for unstable angina were classified into three groups. Group A included 26 patients with postinfarction angina; group B comprised 26 patients with new onset angina; and group C included 33 patients with crescendo angina. Mean PAP levels were higher in the three groups compared to healthy controls. A significant correlation was found between levels of PAP and D-dimer, particularly in postinfarction angina (r = 0.6; p <0.0005). This trial adds new insights into the pathophysiology of unstable angina. It demonstrates that plasmin is generated in the different settings of unstable angina but particularly in postinfarction angina patients where a fibrin-rich thrombus is responsible of the symptoms. However, in this series PAP levels do not predict an uneventful outcome neither in the acute phase nor at long term (6 months). Abbreviations and acronyms: CABG: coronary artery bypass graft; CCU: coronary care unit; ECG: electrocardiogram; IABP: intraaortic balloon pump; MI: myocardial infarction; PAP: plasmin-α2 antiplasmin complexes; PTCA: percutaneous transluminal coronary angioplasty
影响因子：
37.8
作者：
Beat J. Meyer;J. Badimón;A. Mailhac;Antonio Fernández-Ortiz;J. Chesebro;V. Fuster;L. Badimón
通讯作者：
Beat J. Meyer;J. Badimón;A. Mailhac;Antonio Fernández-Ortiz;J. Chesebro;V. Fuster;L. Badimón