The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes.
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes.
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DOI：
10.1016/j.ceca.2011.08.005
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发表时间：
2011-12
期刊：
影响因子：
4
通讯作者：
Nunemaker CS
中科院分区：
文献类型：
--
作者：
Ramadan JW;Steiner SR;O'Neill CM;Nunemaker CS
细胞内钙的适当调节是正常细胞功能和存活的必要条件。本文综述了促炎细胞因子对产生胰岛素的胰腺β细胞中钙调节的影响，以及如何影响正常的刺激-分泌偶联、细胞器功能和整体β细胞活力。促炎细胞因子越来越多地被认为不仅在1型糖尿病（T1 D）中，而且在2型糖尿病（T2 D）的进展中促进β细胞功能障碍。细胞因子诱导的钙处理中断导致响应于葡萄糖刺激的胰岛素释放减少。细胞因子可以通过耗尽内质网（ER）中的钙和增加细胞外间隙的钙流入来改变细胞内钙水平。消耗ER钙导致蛋白质错误折叠和ER应激反应的激活。破坏细胞内钙也可能影响细胞器，包括线粒体和细胞核。作为一种慢性疾病，尼古丁诱导的钙离子中断可能导致T1 D和T2 D中的β细胞死亡，尽管也讨论了可能的保护作用。因此，钙是正常和病理细胞过程的核心。由于细胞内钙的严格调节对体内平衡至关重要，因此测量钙的动态可以作为整体β细胞功能的良好指标。
The appropriate regulation of intracellular calcium is a requirement for proper cell function and survival. This review focuses on the effects of proinflammatory cytokines on calcium regulation in the insulin-producing pancreatic beta-cell and how normal stimulus-secretion coupling, organelle function, and overall beta-cell viability are impacted. Proinflammatory cytokines are increasingly thought to contribute to beta-cell dysfunction not only in type 1 diabetes (T1D), but also in the progression of type 2 diabetes (T2D). Cytokine-induced disruptions in calcium handling result in reduced insulin release in response to glucose stimulation. Cytokines can alter intracellular calcium levels by depleting calcium from the endoplasmic reticulum (ER) and by increasing calcium influx from the extracellular space. Depleting ER calcium leads to protein misfolding and activation of the ER stress response. Disrupting intracellular calcium may also affect organelles, including the mitochondria and the nucleus. As a chronic condition, cytokine-induced calcium disruptions may lead to beta-cell death in T1D and T2D, although possible protective effects are also discussed. Calcium is thus central to both normal and pathological cell processes. Because the tight regulation of intracellular calcium is crucial to homeostasis, measuring the dynamics of calcium may serve as a good indicator of overall beta-cell function.
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影响因子：
16.1
作者：
Busija, David W.;Gaspar, Tamas;Domoki, Ferenc;Katakam, Prasad V.;Bari, Ferenc
通讯作者：
Bari, Ferenc
影响因子：
5.8
作者：
Boeni-Schnetzler, M.;Ehses, J. A.;Donath, M. Y.
通讯作者：
Donath, M. Y.
影响因子：
3.2
作者：
Araki, E;Oyadomari, S;Mori, M
通讯作者：
Mori, M
影响因子：
56.9
作者：
BENDTZEN, K;MANDRUPPOULSEN, T;SVENSON, M
通讯作者：
SVENSON, M
影响因子：
7.7
作者：
Chambers, Kari T.;Unverferth, Juhe A.;Corbett, John A.
通讯作者：
Corbett, John A.