A DETAILED HISTOLOGICAL STUDY ON OCCULT METASTASIS OF THE LYMPH-NODES
A DETAILED HISTOLOGICAL STUDY ON OCCULT METASTASIS OF THE LYMPH-NODES
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DOI：
10.1007/bf02470990
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发表时间：
1991-09-01
期刊：
影响因子：
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通讯作者：
SHIMAZU, H
中科院分区：
文献类型：
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作者：
NATSUGOE, S;AIKO, T;SHIMAZU, H
在常规检查中，每个淋巴结的一个有代表性的显微切片被仔细检查是否有转移。为了仔细检查隐匿性转移的存在，然后从剩余的淋巴结的一半做了另外三个切片。对55例食道癌、胃癌、结肠癌、甲状腺癌或乳腺癌患者的1,698个淋巴结进行了组织学复查。最初的检查不能证明这些淋巴结有任何转移。然而，在复查时，在7名患者的10个结节中检测到癌细胞受累。转移灶最大直径0.2~1.3 mm，半数以上小于0.5 mm。结节内转移类型可分为边缘窦型、髓窦型和混合型。边缘窦型最常见，混合型次之，髓窦型仅1例。因此，外科医生应考虑到隐匿性转移的可能性，并应仔细检查淋巴结的边缘窦，以发现任何微小的转移灶。
One representative microsection from each lymph node was carefully surveyed for metastasis in a routine examination. To scrutinize the existence of occult metastasis, three additional sections were then made from half of the remaining lymph node. A total of 1,698 lymph nodes taken from 55 patients with carcinoma of the esophagus, stomach, colon, thyroid or breast were thus reexamined histologically. The initial examination was not able to prove any metastasis in these lymph nodes. Upon reexamination, however, involvement by cancer cells was detected in 10 nodes of 7 patients. The maximum diameter of the metastatic foci varied from 0.2 mm to 1.3 mm and was less than 0.5 mm in more than half of the nodes. The metastatic patterns in the nodes were classified into three types, i.e., marginal sinus type, medullary sinus type and mixed type. The marginal sinus type was the most frequent, with the mixed type being next and the medullary sinus type being found in only one node. Accordingly, surgeons should keep the possibility of occult metastasis in mind and the marginal sinus of the lymph node should be carefully examined in order to detect any small foci of metastasis.