Genetic differences in tolerance and sensitization to the sedative hypnotic effects of alcohol
Genetic differences in tolerance and sensitization to the sedative hypnotic effects of alcohol
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DOI：
10.1016/0091-3057(95)02055-1
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发表时间：
1996-03-01
影响因子：
3.6
通讯作者：
Froehlich, JC
中科院分区：
文献类型：
--
作者：
Kurtz, DL;Stewart, RB;Froehlich, JC
观察了选择性选育的偏爱酒精(P)和非偏爱(NP)品系的大鼠对酒精的初始敏感性和酒精耐受性的发展。所有大鼠均接受两次酒精注射(3.0g/kg体重，ip)，间隔1天或2天。与NP大鼠相比，P大鼠对酒精的行为损害不那么敏感，表现为在初次注射酒精后，丧失翻正反射(RR)的潜伏期更长，恢复RR的时间更短。当两次注射酒精间隔1d时，P大鼠在第二次注射酒精后恢复RR的速度比第一次快，这表明P大鼠对酒精的镇静/催眠作用产生了耐受。相反，NP大鼠在第二次注射后恢复RR的速度比第一次慢，这表明NP大鼠对酒精产生了敏感性。当两次注射酒精间隔2天时，P系的耐受性和NP系的致敏作用消失。对酒精行为损害效应的初始敏感性和耐受性/敏感度的品系差异可能是在P和NP品系中观察到的酒精消费差异的原因。
Initial sensitivity to alcohol and the development of alcohol tolerance were examined in rats of the selectively bred alcohol-preferring (P) and -nonpreferring (NP) lines. All rats received two alcohol injections (3.0 g/kg b.wt., IP) separated by either 1 or 2 days. P rats were less sensitive to the behaviorally impairing effects of alcohol than were NP rats, as evidenced by a longer latency to lose righting reflex (RR) and a shorter time to recover RR following an initial alcohol injection. When 1 day separated the two alcohol injections, P rats recovered the RR more rapidly following a second injection compared to the first, indicating that the P rats developed tolerance to the sedative/hypnotic effects of alcohol. In contrast, the NP rats recovered the RR more slowly following the second injection compared to the first, indicating that the NP rats developed sensitization to alcohol. Tolerance in the P line and sensitization in the NP line disappeared when 2 days separated the two alcohol injections. Line differences in initial sensitivity and tolerance/sensitization to the behaviorally impairing effects of alcohol may contribute to the differences in alcohol consumption observed in the P and NP lines.