Beyond the snapshot: optimizing prognostication and prediction by moving from fixed to functional multidimensional cancer pathology.
Beyond the snapshot: optimizing prognostication and prediction by moving from fixed to functional multidimensional cancer pathology.
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DOI：
10.1002/path.5915
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发表时间：
2022-07
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影响因子：
--
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随着时间的推移，病理学在患者管理中的作用已经从细胞、组织和疾病的回顾性回顾（“发生了什么”）发展到前瞻性展望（“将会发生什么”）。传统上，静态二维苏木精和伊红（H&E）染色组织载玻片的检查是病理学家的主要任务，但技术突破所带来的新辅助技术支持病理学家提高预测疾病状态和行为的能力。尽管如此，2D固定组织的信息极限现在已经达到，迫切需要技术创新，以确保我们对疾病实体的理解继续支持改进的个性化治疗方案。在这里，我们回顾了癌症病理学领域目前正在进行的开创性工作，这些工作有可能捕获超出当前基本快照的信息。一个令人兴奋的新技术的选择进行了讨论，承诺促进整合的功能和多维（空间和时间）的信息，优化癌症病理学的预后和预测价值。学习如何分析，解释和应用这些新方法获得的丰富数据将挑战病理学界的知识和技能。版权所有© 2022作者。病理学杂志由John Wiley & Sons Ltd代表大不列颠和爱尔兰病理学会出版。
The role of pathology in patient management has evolved over time from the retrospective review of cells, tissue, and disease (‘what happened’) to a prospective outlook (‘what will happen’). Examination of a static, two‐dimensional hematoxylin and eosin (H&E)‐stained tissue slide has traditionally been the pathologist's primary task, but novel ancillary techniques enabled by technological breakthroughs have supported pathologists in their increasing ability to predict disease status and behaviour. Nevertheless, the informational limits of 2D, fixed tissue are now being reached and technological innovation is urgently needed to ensure that our understanding of disease entities continues to support improved individualized treatment options. Here we review pioneering work currently underway in the field of cancer pathology that has the potential to capture information beyond the current basic snapshot. A selection of exciting new technologies is discussed that promise to facilitate integration of the functional and multidimensional (space and time) information needed to optimize the prognostic and predictive value of cancer pathology. Learning how to analyse, interpret, and apply the wealth of data acquired by these new approaches will challenge the knowledge and skills of the pathology community. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
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64.5
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通讯作者：
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