Construction and use of a replication-competent human immunodeficiency virus (HIV-1) that expresses the chloramphenicol acetyltransferase enzyme.
Construction and use of a replication-competent human immunodeficiency virus (HIV-1) that expresses the chloramphenicol acetyltransferase enzyme.
复制标题
表达氯霉素乙酰转移酶的具有复制能力的人类免疫缺陷病毒（HIV-1）的构建和使用。
DOI：
10.1073/pnas.86.10.3857
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发表时间：
1989
影响因子：
11.1
通讯作者：
Haseltine,WA
中科院分区：
文献类型：
--
作者：
Terwilliger,EF;Godin,B;Sodroski,JG;Haseltine,WA
描述了表达细菌基因氯霉素乙酰转移酶的传染性人类免疫缺陷病毒（HIV）的构建和特性。这种病毒可用于体外筛选抑制HIV感染的药物。标记的病毒还可用于动物实验中从接种部位追踪感染途径。
The construction and properties of an infectious human immunodeficiency virus (HIV) that expresses the bacterial gene chloramphenicol acetyltransferase are described. This virus can be used in vitro to screen for drugs that inhibit HIV infection. The marked virus may also be used to trace the routes of infection from the site of inoculation in animal experiments.