Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants
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DOI：
10.1016/j.jaci.2011.01.039
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发表时间：
2011-03-01
影响因子：
14.2
通讯作者：
Allen, Katrina J.
中科院分区：
文献类型：
--
作者：
Osborne, Nicholas J.;Koplin, Jennifer J.;Allen, Katrina J.
背景：一些指标表明，婴儿食物过敏是常见的，并可能增加。很少有研究在人口水平上使用口服食物挑战来衡量这一现象。目的：通过使用预先确定的食物激发标准来衡量结果，测量以人群为基础的12个月婴儿样本中常见的ige介导的儿童食物过敏的患病率。方法：采用抽样框架选择招募地区，形成具有代表性的人口基数。招募发生在澳大利亚墨尔本的儿童免疫会议上。婴儿进行皮肤点刺试验，并邀请对一种或多种食物（生鸡蛋、花生、芝麻、贝类或牛奶）有任何过敏反应（轮大小>= 1毫米）的婴儿参加过敏研究诊所。那些对生鸡蛋、花生或芝麻的轮大小为>= 1毫米的人进行了口腔食物挑战。结果：在2848名婴儿（73%的参与率）中，花生致敏率为8.9% (95% CI, 7.9-10.0)；生蛋清，16.5% (95% CI, 15.1-17.9)；芝麻，2.5% (95% CI, 2.0-3.1)；牛奶，5.6% (95% CI, 3.2-8.0)；贝类，0.9% （95% CI, 0.6-1.5）。经激射证实的花生过敏患病率为3.0% (95% CI, 2.4-3.8)；生鸡蛋过敏，8.9% (95% CI, 7.8-10.0)；芝麻过敏，0.8% （95% CI, 0.5-1.1）。没有对牛奶和贝类进行口服食物挑战。在生鸡蛋过敏的人中，80.3%的人可以忍受烤鸡蛋。结论：超过10%的1岁婴儿对婴儿常见的致敏食物之一有ige介导的食物过敏。过敏性疾病在澳大利亚的高患病率需要进一步调查，可能与可改变的环境因素有关。[J] .中华过敏症杂志，2011;27:668- 676。
Background: Several indicators suggest that food allergy in infants is common and possibly increasing. Few studies have used oral food challenge to measure this phenomenon at the population level.Objective: To measure the prevalence of common IgE-mediated childhood food allergies in a population-based sample of 12-month-old infants by using predetermined food challenge criteria to measure outcomes.Methods: A sampling frame was used to select recruitment areas to attain a representative population base. Recruitment occurred at childhood immunization sessions in Melbourne, Australia. Infants underwent skin prick testing, and those with any sensitization (wheal size >= 1 mm) to 1 or more foods (raw egg, peanut, sesame, shellfish, or cow's milk) were invited to attend an allergy research clinic. Those who registered a wheal size >= 1 mm to raw egg, peanut, or sesame underwent oral food challenge.Results: Amongst 2848 infants (73% participation rate), the prevalence of any sensitization to peanut was 8.9% (95% CI, 7.9-10.0); raw egg white, 16.5% (95% CI, 15.1-17.9); sesame, 2.5% (95% CI, 2.0-3.1); cow's milk, 5.6% (95% CI, 3.2-8.0); and shellfish, 0.9% (95% CI, 0.6-1.5). The prevalence of challenge-proven peanut allergy was 3.0% (95% CI, 2.4-3.8); raw egg allergy, 8.9% (95% CI, 7.8-10.0); and sesame allergy, 0.8% (95% CI, 0.5-1.1). Oral food challenges to cow's milk and shellfish were not performed. Of those with raw egg allergy, 80.3% could tolerate baked egg.Conclusion: More than 10% of 1-year-old infants had challenge-proven IgE-mediated food allergy to one of the common allergenic foods of infancy. The high prevalence of allergic disease in Australia requires further investigation and may be related to modifiable environmental factors. (J Allergy Clin Immunol 2011;127:668-76.)