Drug-drug interactions between anti-retroviral therapies and drugs of abuse in HIV systems.
Drug-drug interactions between anti-retroviral therapies and drugs of abuse in HIV systems.
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抗逆转录病毒疗法与艾滋病毒系统滥用药物之间的药物相互作用。
DOI：
10.1517/17425255.2015.996546
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发表时间：
2015-03
影响因子：
4.3
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Kumar S;Rao PS;Earla R;Kumar A
药物滥用是艾滋病毒感染者的一个普遍问题。重要的是，成瘾以及适度使用酒精、吸烟或其他非法药物已被确定为艾滋病毒患者不坚持抗逆转录病毒治疗（ART）的主要原因。文献还表明，使用这些药物的艾滋病毒患者对抗逆转录病毒治疗的反应降低，导致无法达到最佳病毒学反应和疾病进展加快。本综述讨论了坚持抗逆转录病毒治疗所面临的挑战，以及观察到的药物相互作用和与主要滥用药物（如酒精、吸烟、甲基苯丙胺、可卡因、大麻和阿片类药物）的已知毒性。缺乏依从性和药物相互作用可能导致抗逆转录病毒治疗药物的疗效下降和抗逆转录病毒治疗药物的增加，以及药物滥用介导的毒性。由于CYP是代谢抗逆转录病毒药物和滥用药物的共同途径，我们讨论CYP途径可能参与这种药物相互作用。我们认识到，进一步研究涉及CYP的常见代谢途径和在这一领域的深入研究将有助于开发新的/替代干预措施和药物剂量/方案调整，以改善滥用药物的艾滋病毒患者的用药结果。
Substance abuse is a common problem among HIV-infected individuals. Importantly, addictions as well as moderate use of alcohol, smoking, or other illicit drugs have been identified as major reasons for non-adherence to antiretroviral therapy (ART) among HIV patients. The literature also suggests a decrease in the response to ART among HIV patients who use these substances, leading to failure to achieve optimal virological response and increased disease progression. This review discusses the challenges with adherence to ART as well as observed drug interactions and known toxicities with major drugs of abuse, such as alcohol, smoking, methamphetamine, cocaine, marijuana, and opioids. The lack of adherence and drug interactions potentially lead to decreased efficacy of ART drugs and increased ART, and drugs of abuse-mediated toxicity. As CYP is the common pathway in metabolizing both ART and drugs of abuse, we discuss the possible involvement of CYP pathways in such drug interactions. We acknowledge that further studies focusing on common metabolic pathways involving CYP and advance research in this area would help to potentially develop novel/alternate interventions and drug dose/regimen adjustments to improve medication outcomes in HIV patients who consume drugs of abuse.
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影响因子：
1
作者：
Cisneros IE;Ghorpade A
通讯作者：
Ghorpade A
影响因子：
3.8
作者：
Bornheim, LM
通讯作者：
Bornheim, LM
影响因子：
3.9
作者：
Bao, ZP;He, XY;Hong, JY
通讯作者：
Hong, JY
DOI：
10.1515/jbcpp-2013-0089
发表时间：
2014-01-27
影响因子：
--
作者：
Bbosa, Godfrey S;Kyegombe, David B;Ntale, Muhammad
通讯作者：
Ntale, Muhammad
影响因子：
39.2
作者：
Abrams, DI;Hilton, JF;Schambelan, M
通讯作者：
Schambelan, M