Passive deformations and active motions of leukocytes.
Passive deformations and active motions of leukocytes.
复制标题
白细胞的被动变形和主动运动。
DOI：
10.1115/1.2891187
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Zhu,C
中科院分区：
文献类型：
--
作者：
Skalak,R;Dong,C;Zhu,C
本文的目的是回顾发展的连续介质力学模型的单白细胞在被动变形和主动运动，并指出一些未来的发展方向。被动变形模型描述了单个白细胞在外力作用下的整体流变行为，并从实验数据预测平均力学性能。各种“表观”粘弹性系数，获得取决于所假设的模型和所使用的测试类型。自发运动的模型假设主动驱动机制，这些机制必须来自细胞本身的内部，并且对于不同类型的运动可能具有不同的基础。对于白细胞上的伪足突起，假设从化学势到与突起尖端的肌动蛋白聚合相关的机械功的能量转换提供动力。对于伪足收缩，主动收缩由于肌动蛋白-肌球蛋白相互作用被认为是驱动力。通过数值算例和理论计算结果与实验测量结果的比较，验证了假设的可行性。
The purpose of this paper is to review the development of continuum mechanics models of single leukocytes in both passive deformations and active motions and to indicate some future directions. Models of passive deformations describe the overall rheological behavior of single leukocytes under externally applied forces and predict the average mechanical properties from experimental data. Various “apparent” viscoelastic coefficients are obtained depending on the models assumed and the types of test used. Models of spontaneous motions postulate active driving mechanisms which must be derived internally from the cell itself and probably have different bases for different kind of motions. For pseudopod protrusion on leukocytes, energy transduction from chemical potential to mechanical work associated with actin polymerization at the tip of the projection is assumed to supply the motive power. For pseudopod retraction, active contraction due to actin-myosin interaction is assumed to be the driving force. The feasibility of the hypotheses are tested via numerical examples and comparison of the theoretical results with experimental measurements.