A new biometric: In utero growth curves for metacarpal and phalangeal lengths reveal an embryonic patterning ratio.
A new biometric: In utero growth curves for metacarpal and phalangeal lengths reveal an embryonic patterning ratio.
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DOI：
10.1002/pd.5397
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发表时间：
2019-03
影响因子：
3
通讯作者：
Krakow D
中科院分区：
文献类型：
--
作者：
Rao R;Gornbein J;Afshar Y;Platt LD;DeVore GR;Krakow D
制定胎儿第三掌骨和指骨长度的孕龄特定生长曲线，并确定胎儿手部比例是否在子宫内建立。这项前瞻性横断面研究使用 12-39 周孕龄的 2D 超声来评估胎儿第三掌骨和指骨的测量结果。制定了特定胎龄的参考生长曲线。使用 Spearman 相关性 (rs) 和限制三次样条评估连续变量之间的关联。使用非线性生物回归模型来预测掌骨和指骨长度作为胎龄的函数。来自五例致死性发育不良病例的测量结果被用来确定短指是否可以客观化。胎儿掌骨和指骨长度与孕龄高度相关（rs=0.96，p<0.001）。胎儿掌骨与指骨的平均比例从胎龄 15 周到 39 周保持恒定（rs =−0.07，p=0.49）。所有病例 (5/5) 的致死性发育不良的第三位数掌骨和指骨长度均显示短指，并且没有病例 (0/5) 表现出正常的掌骨与指骨比率 0.49。我们提出了胎儿第三掌骨和指骨长度的孕龄特定参考生长曲线，可用于检测短指。我们证明产前掌骨与指骨的比例为 1:2。
Develop gestational age specific growth curves for fetal third metacarpal and phalangeal lengths and determine if fetal hand proportion is established in utero. This prospective cross-sectional study used 2D ultrasound across gestational ages 12–39 weeks to evaluate the third fetal metacarpal and phalangeal measurements. Gestational age specific reference growth curves were developed. Associations between continuous variables were assessed using Spearman correlations (rs) and restricted cubic splines. A nonlinear biologic regression model was used to predict metacarpal and phalangeal length as a function of gestational age. Measurements derived from five cases of thanatophoric dysplasia were used to determine if brachydactyly could be objectified. Fetal metacarpal and phalangeal lengths are highly correlated across gestational age (rs=0.96, p<0.001). The mean fetal metacarpal to phalangeal ratio is constant from gestational age 15 to 39 weeks (rs =−0.07, p=0.49). Third-digit metacarpal and phalangeal lengths in thanatophoric dysplasia showed brachydactyly in all cases (5/5), and none of the cases (0/5) demonstrated a normal metacarpal to phalangeal ratio of 0.49. We present gestational age specific reference growth curves for fetal third metacarpal and phalangeal lengths, which may be used to detect brachydactyly. We demonstrate a prenatal metacarpal to phalangeal ratio of 1:2.
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DOI：
10.1002/ajmg.10062
发表时间：
2001-11-22
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
Unger, S;Korkko, J;Cohn, DH
通讯作者：
Cohn, DH
影响因子：
7.1
作者：
Tovbin, J;Maymon, R;Herman, A
通讯作者：
Herman, A
影响因子：
2
作者：
Xue, Yuan;Sun, Angela;Wilcox, William R.
通讯作者：
Wilcox, William R.
影响因子：
7.1
作者：
den Hollander, NS;Hoogeboom, AJM;Wladimiroff, JW
通讯作者：
Wladimiroff, JW
影响因子：
2.3
作者：
Doubilet, PM;Benson, CB;Ringer, SA
通讯作者：
Ringer, SA