Point-source outbreak of coccidioidomycosis in construction workers
Point-source outbreak of coccidioidomycosis in construction workers
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DOI：
10.1017/s0950268809990999
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发表时间：
2010-04-01
影响因子：
4.2
通讯作者：
Mohle-Boetani, J. C.
中科院分区：
文献类型：
--
作者：
Cummings, K. C.;McDowell, A.;Mohle-Boetani, J. C.
球孢子菌病是由吸入球孢子菌属真菌的孢子引起的。流行地区的土壤或空气中的灰尘中。 2007 年 10 月，我们调查了加利福尼亚州罗伯茨军营军事基地地下管道安装过程中挖掘土壤的 12 名民用建筑人员爆发的球孢子菌病。10 名工人 (83.3%) 出现了球孢子菌病症状； 8 例 (66-7%) 经血清学确诊患有疾病，7 例胸部 X 光片异常，1 例出现播散性感染；没有人使用呼吸防护装置。第 11 名工人在 2008 年接触过疫情爆发地点后被诊断为球孢子菌病。尽管罗伯茨营曾发生过偶发性聚集性感染，但该地区与加利福尼亚州圣华金谷的高发病率无关。在任何球孢子虫流行地区（包括仅有历史证据表明疾病活动的地区）开始工作之前，应采取措施尽量减少土壤破坏活动期间接触空气中孢子的风险。
Coccidioidomycosis results from inhaling spores of the fungus Coccidioides spp. in soil or airborne dust in endemic areas. We investigated an outbreak of coccidioidomycosis in a 12-person civilian construction crew that excavated soil during an underground pipe installation on Camp Roberts Military Base, California in October 2007. Ten (83.3%) workers developed symptoms of coccidioidomycosis; eight (66-7%) had serologically confirmed disease, seven had abnormal chest radiographs, and one developed disseminated infection; none used respiratory protection. A diagnosis of coccidioidomycosis in an eleventh worker followed his exposure to the outbreak site in 2008. Although episodic clusters of infections have occurred at Camp Roberts, the general area is not associated with the high disease rates found in California's San Joaquin Valley. Measures to minimize exposure to airborne spores during soil-disrupting activities should be taken before work begins in any coccidioides-endemic area, including regions with only historic evidence of disease activity.