Effect of somatostatin analogs on gastric acid secretion in dogs and rats.
Effect of somatostatin analogs on gastric acid secretion in dogs and rats.
复制标题
生长抑素类似物对狗和大鼠胃酸分泌的影响。
DOI：
10.1111/j.1399-3011.1990.tb00977.x
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Cai,RZ
中科院分区：
文献类型：
--
作者：
Schally,AV;Colaluca,J;Paulson,D;Carter,WH;Neitzschman,HR;Lafaye,H;Cai,RZ
在患有胃瘘（GF）的清醒狗和大鼠中研究了生长抑素的几种超活性类似物对胃酸对各种外源性和内源性刺激物的反应的影响。将这种抑制与生长抑素-14 (S-S-14) 在两个剂量水平下诱导的抑制进行比较。生长抑素的几种八肽类似物，包括 (RC-160) 和 (RC-121)，在抑制 GH 水平的测试中表现出超活性，在抑制 GF 狗中去谷胃泌素刺激的胃酸分泌方面，其效力比 S-S-14 强 4-5 倍。类似物 RC-160 还降低了患有胃和食管瘘 (EF) 的狗因假喂养 (SF) 引起的血清胃泌素水平和胃酸分泌的升高，但并没有减少食物消耗。狗组胺（80μg/kg/h）诱导的胃酸分泌不受1-5μg/kg/h类似物RC-121或5μg/kg/h S-S-14的影响。类似物 RC-160、RC-121 和 RC-98-I 等也能有效抑制 GF 大鼠中去谷胃泌素诱导的胃酸分泌。环六肽（-Pro-Phe-D-Trp-Lys-Thr-Phe）在狗中的效力仅为 S-S-14 的一半左右，但在大鼠中的活性更高。结果表明，在 GH 抑制测试中具有超活性的八肽类似物在抑制胃酸分泌方面也比 S-S-14 更有效。这些发现可能具有临床价值。
The effects of several superactive analogs of somatostatin on gastric acid response to various exogenous and endogenous stimulants were investigated in conscious dogs and rats with gastric fistulae (GF). The inhibition was compared to that induced by somatostatin‐14 (S‐S‐14) at two dose levels. Several octapeptide analogs of somatostatin including (RC‐160) and (RC‐121), which were superactive in tests on suppression of GH levels, were 4‐5 times more potent than S‐S‐14 in inhibiting desglugastrin‐stimulated gastric acid secretion in GF dogs. The analog RC‐160 also reduced the rise in serum gastrin levels and gastric acid secretion induced by sham feeding (SF) in dogs with gastric and esophageal fistulae (EF), but did not decrease food consumption. Gastric acid secretion induced by histamine (80μg/kg/h) in dogs was not affected by 1‐5μg/kg/h of analog RC‐121 or by 5μg/kg/h of S‐S‐14. Analogs RC‐160, RC‐121, and RC‐98‐I and others also powerfully inhibited desglugastrin‐induced gastric acid secretion in GF rats. Hexapeptide cyclo(‐Pro‐Phe‐D‐Trp‐Lys‐Thr‐Phe) was only about half as potent as S‐S‐14 in dogs but its activity was higher in rats. The results indicate that octapeptide analogs which are superactive in GH‐inhibition tests are also more potent than S‐S‐14 in suppressing gastric acid secretion. These findings may be of clinical value.