The prevalence of multiple sleep-onset REM periods in a population-based sample.
The prevalence of multiple sleep-onset REM periods in a population-based sample.
复制标题
基于人群的样本中多个睡眠开始快速眼动期的患病率。
DOI：
10.1093/sleep/29.7.890
复制
发表时间：
2006
期刊：
影响因子：
5.6
通讯作者：
Roth,Thomas
中科院分区：
文献类型：
--
作者：
Singh,Meeta;Drake,ChristopherL;Roth,Thomas
多次睡眠潜伏期测试（MPEST）中出现2个或更多个睡眠发作性快速眼动期（SOREMP）已被用作诊断发作性睡病的标准之一，并被认为是这种疾病的特异性。然而，先前的研究表明SOREMPS在健康志愿者和呼吸暂停患者中的患病率高于预期。本研究在密歇根州东南部的代表性人群样本中确定了2种或2种以上SOREMP的患病率，并调查了与其他睡眠相关变量的潜在关联。设计基于实验室的横断面分析。设置睡眠障碍诊所。基于人群的样本。干预措施N/A。测量333名受试者的基于人群的样本通过夜间多导睡眠图和日间睡眠监测（5次小睡）进行评估，另外还评估了206名主观嗜睡的人（总共= 539）。抽样人口统计数据与2000年人口普查数据相当。还测定了埃普沃思嗜睡量表评分。根据每个睡眠变量（埃普沃思嗜睡量表，MPEG4，总睡眠时间从夜间多导睡眠图）的中位数分裂SOREMPs在每个group.ResultsThe患病率的比较SOREMPs为3.9%。只有平均睡眠潜伏期在MIPs上是存在2个或更多SOREMP的一个优势（短潜伏期= 6.3%，长潜伏期= 1.9%，p <0.05）。在谁有一个5分钟或更少的MREMP（嗜睡的病理水平的指标）的受试者，9.5%有2个或更多SOREMPs.ConclusionsThe总体患病率2个或更多SOREMPs在我们的样本是3.9%。有趣的是，在评估的变量中（MPEG4、埃普沃思嗜睡量表和夜间多导睡眠描记术的总睡眠时间），MPEG4确定的客观嗜睡是与2种或2种以上SOREMP显著相关的唯一指标。因此，过度嗜睡的亚群（如轮班工人、年轻人、呼吸暂停患者）可能有更高的SOREMP患病率。
Study ObjectiveThe presence of 2 or more sleep-onset rapid eye movement periods (SOREMPs) on a Multiple Sleep Latency Test (MSLT) has been used as 1 of the criteria for the diagnosis of narcolepsy and is thought to be specific to this disorder. However, previous studies have shown the prevalence of SOREMPS in healthy volunteers and apneic patients to be higher than expected. The present study determined the prevalence of 2 or more SOREMPs in a representative sample of the population from southeast Michigan and investigated potential associations with other sleep-related variables.DesignCross-sectional laboratory-based analysis.SettingsSleep disorders clinic.ParticipantsPopulation-based sample.InterventionsN/A.MeasurementsA population-based sample of 333 subjects was assessed by nocturnal polysomnography and daytime MSLT (5 naps), and an additional 206 subjectively sleepy people were also assessed (total = 539). Sample demographics were comparable to the 2000 census. Epworth Sleepiness Scale scores were also determined. Groups were formed based on a median split of each sleep variable (Epworth Sleepiness Scale, MSLT, total sleep time from nocturnal polysomnography) for comparisons of SOREMPs in each group.ResultsThe prevalence of 2 or more SOREMPs was 3.9%. Only mean sleep latency on the MSLT was a discriminator for the presence of 2 or more SOREMPs (short latency = 6.3%, long latency = 1.9%, p < .05). Among the subjects who had an MSLT of 5 minutes or less (an indicator of a pathologic level of sleepiness), 9.5% had 2 or more SOREMPS.ConclusionsThe overall prevalence of 2 or more SOREMPs in our sample is 3.9%. Interestingly, of the variables assessed (MSLT, Epworth Sleepiness Scale, and total sleep time from nocturnal polysomnography), objective sleepiness, as determined by the MSLT, was the only measure significantly associated with 2 or more SOREMPs. Therefore, subpopulations with excessive sleepiness (eg, shift workers, young adults, patients with apnea) are likely to have a greater prevalence of SOREMPs.