Fully Immersible Subcortical Neural Probes With Modular Architecture and a Delta-Sigma ADC Integrated Under Each Electrode for Parallel Readout of 144 Recording Sites
Fully Immersible Subcortical Neural Probes With Modular Architecture and a Delta-Sigma ADC Integrated Under Each Electrode for Parallel Readout of 144 Recording Sites
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DOI：
10.1109/jssc.2018.2873180
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发表时间：
2018-11-01
影响因子：
5.4
通讯作者：
Manoli, Yiannos
中科院分区：
文献类型：
--
作者：
De Dorigo, Daniel;Moranz, Christian;Manoli, Yiannos
本文介绍了一种针形神经探针，它在每个电极下集成了一个增量Delta Sigma-ADC，面积为70 x 70 μ m（2）。模块化架构避免了噪声敏感神经信号的全局路由，并与数字四线接口连接。可重新配置的5.6/11.5 mm针能够并行读取所有64/144个集成记录部位，并具有从上到下恒定的70 x50 μ m（2）宽度和厚度，允许完全植入用于脑深部监测应用。铂或铱氧化物电极可以在定制的后CMOS工艺中沉积。记录系统的功能在体内设置中得到证明。在每个记录点的功耗为39.14 μ W时，LFP信号（1-300 Hz）的噪声性能为6.02 μ V-rms，AP信号（300 Hz-10 kHz）的噪声性能为10.46 μ V-rms。
This paper presents a needle-shaped neural probe which integrates an incremental Delta Sigma-ADC under each electrode in an area of 70 x 70 mu m(2). The modular architecture avoids global routing of noise sensitive neural signals and connects with a digital four-wire interface. The re-configurable 5.6/11.5 mm needle enables parallel readout of all 64/144 integrated recording sites and features a constant width and thickness of 70x50 mu m(2) from top to bottom allowing to be fully implanted for deep brain monitoring applications. Platinum or iridium-oxide electrodes can be deposited in a custom post-CMOS process. The functionality of the recording system is demonstrated in an in vivo setup. The noise performance of 6.02 mu V-rms for LFP signals (1-300 Hz) and 10.46 mu V-rms for AP signals (300 Hz-10 kHz) is obtained at a power consumption of 39.14 mu W per recording site.