Challenges in diagnosing type 1 diabetes in different populations.
Challenges in diagnosing type 1 diabetes in different populations.
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DOI：
10.4093/dmj.2012.36.2.90
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发表时间：
2012-04
影响因子：
5.9
通讯作者：
Rewers M
中科院分区：
文献类型：
--
作者：
Rewers M
糖尿病目前影响全世界约3.66亿人，包括2000万至4000万1型糖尿病（T1D）患者。虽然T1D占糖尿病患者的5%至20%，但与更普遍的2型糖尿病相比，它与更高的发病率，死亡率和医疗保健成本相关。T1D患者需要外源性胰岛素才能生存，应在诊断后尽快确定，以避免由于胰岛素治疗延迟而导致的高发病率。同样重要的是向患者提供因糖尿病类型而异的正确预后。从研究的角度来看，正确的分类应有助于确定病因，并制定具体的预防T1D。本文综述了可能有助于诊断不同种族T1D的证据。强调了在解释通常用于确定糖尿病类型的结果方面的挑战。
Diabetes affects today an estimated 366 million people world-wide, including 20 million to 40 million of patients with type 1 diabetes (T1D). While T1D accounts for 5% to 20% of those with diabetes, it is associated with higher morbidity, mortality and health care cost than the more prevalent type 2 diabetes. Patients with T1D require exogenous insulin for survival and should be identified as soon as possible after diagnosis to avoid high morbidity due to a delay in insulin treatment. It is also important to present to the patient correct prognosis that differs by the type of diabetes. From the research point of view, correct classification should help to identify the etiologies and to develop specific prevention for T1D. This review summarizes evidence that may be helpful in diagnosing T1D in various ethnic groups. Challenges in interpretation of results commonly used to determine the type of diabetes are highlighted.