Investigation of the sensitivity of functional near-infrared spectroscopy brain imaging to anatomical variations in 5- to 11-year-old children.
Investigation of the sensitivity of functional near-infrared spectroscopy brain imaging to anatomical variations in 5- to 11-year-old children.
复制标题
DOI：
10.1117/1.nph.5.1.011009
复制
发表时间：
2018-01
期刊：
影响因子：
5.3
通讯作者：
Huppert T
中科院分区：
文献类型：
--
作者：
Whiteman AC;Santosa H;Chen DF;Perlman S;Huppert T
功能性近红外光谱（fNIRS）是一种非侵入性脑成像技术，使用头皮放置的光传感器来测量脑血氧的诱发变化。便携性、低开销成本以及在广泛的实验环境下使用该技术的能力使得fNIRS非常适合涉及婴儿和儿童的研究。然而，由于fNIRS不直接提供解剖学或结构信息，这些测量可能对与头部大小、大脑距头皮的深度或影响光穿透到头部的其他解剖学因素的变化相关的个体或组水平差异敏感。儿科人群通常无法获得此信息，而儿科人群通常是fNIRS的研究目标。使用90名学龄儿童（5至11岁）的解剖磁共振成像信息来量化脑和脑外结构变化对fNIRS测量的预期影响。组织中的光传输的蒙特卡罗模拟被用来估计差分和部分光程长度在690，780，808，830和850 nm和他们的年龄，性别和头部大小的变化。这项工作提供了查找表，这些值和一般的指导，为今后的调查使用fNIRS无解剖信息，在这个儿童群体。
Functional near-infrared spectroscopy (fNIRS) is a noninvasive brain imaging technique that uses scalp-placed light sensors to measure evoked changes in cerebral blood oxygenation. The portability, low overhead cost, and ability to use this technology under a wide range of experimental environments make fNIRS well-suited for studies involving infants and children. However, since fNIRS does not directly provide anatomical or structural information, these measurements may be sensitive to individual or group level differences associated with variations in head size, depth of the brain from the scalp, or other anatomical factors affecting the penetration of light into the head. This information is generally not available in pediatric populations, which are often the target of study for fNIRS. Anatomical magnetic resonance imaging information from 90 school-age children (5 to 11 years old) was used to quantify the expected effect on fNIRS measures of variations in cerebral and extracerebral structure. Monte Carlo simulations of light transport in tissue were used to estimate differential and partial optical pathlengths at 690, 780, 808, 830, and 850 nm and their variations with age, sex, and head size. This work provides look-up tables of these values and general guidance for future investigations using fNIRS sans anatomical information in this child population.