Experimental and computational approach investigating burst fracture augmentation using PMMA and calcium phosphate cements.
Experimental and computational approach investigating burst fracture augmentation using PMMA and calcium phosphate cements.
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DOI：
10.1007/s10439-013-0959-3
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发表时间：
2014-04
影响因子：
3.8
通讯作者：
Wilcox, Ruth K.
中科院分区：
文献类型：
--
作者：
Tarsuslugil, Sami M.;O'Hara, Rochelle M.;Dunne, Nicholas J.;Buchanan, Fraser J.;Orr, John F.;Barton, David C.;Wilcox, Ruth K.
关键词：
本研究的目的是使用计算和实验方法来评价、比较和预测磷酸钙（CaP）和聚甲基丙烯酸甲酯（PMMA）填充骨水泥在椎体成形术后恢复创伤性骨折椎体机械稳定性的能力。使用落锤法在一系列猪椎骨中产生创伤性骨折（n = 17）。使用μCT对骨折椎骨进行成像，并在轴向压缩下进行测试。随机选择12个骨折椎骨，使用PMMA（n = 6）或CaP骨水泥变体（n = 6）进行椎体成形术。使用μCT对标本进行成像并重新测试。根据μCT数据生成骨折和增强椎骨的有限元模型，并用于比较骨折空隙填充与增强样本刚度的效果。与骨折组相比，两个加固样本组的失效载荷均显著增加（p < 0.05）。实验和计算结果表明，无论是CaP骨水泥还是PMMA骨水泥都不能完全恢复椎体的力学性能到完整的水平。手术的有效性似乎更受填充的骨折体积的影响，而不是骨水泥本身的机械性能。
The aim of the study was to use a computational and experimental approach to evaluate, compare and predict the ability of calcium phosphate (CaP) and poly (methyl methacrylate) (PMMA) augmentation cements to restore mechanical stability to traumatically fractured vertebrae, following a vertebroplasty procedure. Traumatic fractures (n = 17) were generated in a series of porcine vertebrae using a drop-weight method. The fractured vertebrae were imaged using μCT and tested under axial compression. Twelve of the fractured vertebrae were randomly selected to undergo a vertebroplasty procedure using either a PMMA (n = 6) or a CaP cement variation (n = 6). The specimens were imaged using μCT and re-tested. Finite element models of the fractured and augmented vertebrae were generated from the μCT data and used to compare the effect of fracture void fill with augmented specimen stiffness. Significant increases (p < 0.05) in failure load were found for both of the augmented specimen groups compared to the fractured group. The experimental and computational results indicated that neither the CaP cement nor PMMA cement could completely restore the vertebral mechanical behavior to the intact level. The effectiveness of the procedure appeared to be more influenced by the volume of fracture filled rather than by the mechanical properties of the cement itself.
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影响因子：
2.8
作者：
Baroud, G;Nemes, J;Steffen, T
通讯作者：
Steffen, T
影响因子：
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作者：
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作者：
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通讯作者：
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作者：
Dunne, NJ;Orr, JF
通讯作者：
Orr, JF