Connectivity-Based Parcellation of the Human Frontal Pole with Diffusion Tensor Imaging
Connectivity-Based Parcellation of the Human Frontal Pole with Diffusion Tensor Imaging
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DOI：
10.1523/jneurosci.4882-12.2013
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发表时间：
2013-04-17
影响因子：
5.3
通讯作者：
Yu, Chunshui
中科院分区：
文献类型：
--
作者：
Liu, Huaigui;Qin, Wen;Yu, Chunshui
人类额极（FP）大致对应于布罗德曼区10，是一个高度分化的皮质区，具有独特的细胞结构特征。然而，其功能的多样性是高度暗示的功能亚区的存在。基于来自扩散张量成像数据的解剖连接模式，我们应用谱聚类算法将人类右FP分成眶（FPo）、外侧（FPl）和内侧（FPm）子区域。通过在另一个独立数据集中对左FP和右FP进行相应分析，验证了该分组方案。视觉观察和定量比较3个FP亚区的解剖连接模式发现，FPo与社会情绪网络（SEN）的脑区（包括眶额皮质、颞极和杏仁核）的连接概率更高，FPl与认知加工网络（CPN）的背外侧前额叶皮质的连接概率更高，FPm与默认模式网络（DMN）的大脑区域（包括前扣带皮层和内侧前额叶皮层）有更强的联系。我们进一步分析了三个FP亚区的静息态功能连接模式。与解剖连接分析的结果一致，FPo与SEN功能相关，FPl与CPN相关，FPm与DMN相关。这些发现表明，人类FP包括三个可分离的亚区，具有不同的解剖和功能连接模式，这些亚区参与不同的脑功能网络，并发挥不同的功能。
The human frontal pole (FP) approximately corresponds to Brodmann's area 10 and is a highly differentiated cortical area with unique cytoarchitectonic characteristics. However, its functional diversity is highly suggestive of the existence of functional subregions. Based on anatomical connection patterns derived from diffusion tensor imaging data, we applied a spectral clustering algorithm to parcellate the human right FP into orbital (FPo), lateral (FPl), and medial (FPm) subregions. This parcellation scheme was validated by corresponding analyses of the left FP and right FP in another independent dataset. Both visual observation and quantitative comparison of the anatomical connection patterns of the three FP subregions revealed that the FPo showed greater connection probabilities to brain regions of the social emotion network (SEN), including the orbitofrontal cortex, temporal pole, and amygdala, the FPl showed stronger connections to the dorsolateral prefrontal cortex of the cognitive processing network (CPN), and the FPm showed stronger connections to brain areas of the default mode network (DMN), including the anterior cingulate cortex and medial prefrontal cortex. We further analyzed the resting-state functional connectivity patterns of the three FP subregions. Consistent with the findings of anatomical connection analyses, the FPo was functionally correlated with the SEN, the FPl was correlated with the CPN, and the FPm was correlated with the DMN. These findings suggest that the human FP includes three separable subregions with different anatomical and functional connectivity patterns and that these subregions are involved in different brain functional networks and serve different functions.