Cholesterol and copper affect learning and memory in the rabbit.
Cholesterol and copper affect learning and memory in the rabbit.
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DOI：
10.1155/2013/518780
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发表时间：
2013
影响因子：
--
通讯作者：
Schreurs BG
中科院分区：
文献类型：
--
作者：
Schreurs BG
一种阿尔茨海默病的兔子模型，在喂食胆固醇食物8周的基础上，显示出这种疾病的16个特征，包括-淀粉样蛋白积累、学习和记忆变化。虽然我们已经证明，在饮用水中添加2%的胆固醇和铜会阻碍学习，但其他研究表明，在学习前摄入膳食胆固醇可以提高习得性，而在学习后摄入胆固醇会降低长期记忆。我们将探讨这个模型的发展，围绕铜的作用的问题，以及已故的D. Larry Sparks的特殊贡献。
A rabbit model of Alzheimer's disease based on feeding a cholesterol diet for eight weeks shows sixteen hallmarks of the disease including beta amyloid accumulation and learning and memory changes. Although we have shown that feeding 2% cholesterol and adding copper to the drinking water can retard learning, other studies have shown that feeding dietary cholesterol before learning can improve acquisition and feeding cholesterol after learning can degrade long-term memory. We explore the development of this model, the issues surrounding the role of copper, and the particular contributions of the late D. Larry Sparks.