SOLITARY CIRCUMSCRIBED NEUROMA OF THE SKIN (SO-CALLED PALISADED, ENCAPSULATED NEUROMA) - A CLINICOPATHOLOGIC AND IMMUNOHISTOCHEMICAL STUDY
SOLITARY CIRCUMSCRIBED NEUROMA OF THE SKIN (SO-CALLED PALISADED, ENCAPSULATED NEUROMA) - A CLINICOPATHOLOGIC AND IMMUNOHISTOCHEMICAL STUDY
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DOI：
10.1097/00000478-198907000-00005
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发表时间：
1989-07-01
影响因子：
5.6
通讯作者：
FLETCHER, CDM
中科院分区：
文献类型：
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作者：
FLETCHER, CDM
孤立性、局限性神经瘤是一种独特的良性皮肤肿瘤，15年前首次被称为“栅栏状、包裹性神经瘤”。尽管它并不罕见，但它受到的关注很少，在病理学家中知之甚少。本文对39例乳腺癌的临床病理和免疫组化特征进行了研究。在中年人中，病变几乎总是出现在面部或靠近皮肤粘膜交界处。大多数示例测量. 0.5由一团被部分包裹的温和的雪旺氏细胞和无数细小的轴突组成。被膜由上皮膜抗原阳性的神经周细胞组成。孤立的局限性神经瘤与von Recklinghausen神经纤维瘤病无关，也没有证据支持其与IIb型多发性内分泌瘤综合征的可能关系。这一实体应得到更广泛的承认。
Solitary, circumscribed neuroma is a distinctive benign cutneous tumor that was first described under the name "palisaded, encapsulated neuroma" over 15 years ago. Despite the fact that it is not uncommon, it has received minimal attention and is very poorly known among pathologists. We have studied the clinicopathologic and immunohistochemical features of 39 cases. Thee lesions almost always present on the face or close to a mucocutaneous junction in middle-aged adults. Most examples measure .ltoreq. 0.5 cm and are composed of a partially encapsulated mass of bland Schwann cells and innumerable tiny axons arranged in interlacing fascicles. The capsule is composed of perineural cells that show epithelial membrane antigen positivity. Solitary, circumscribed neuroma is not associated with von Recklinghausen''s neurofibromatosis, nor is there evidence to support its possible relationship to the type IIb multiple endocrine neoplasia syndrome. This entity warrants wider recognition.