Intravenous methylprednisolone pulse therapy for children with autoimmune hepatitis
Intravenous methylprednisolone pulse therapy for children with autoimmune hepatitis
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DOI：
10.1016/j.hepres.2005.12.002
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发表时间：
2006-03-01
影响因子：
4.2
通讯作者：
Yokota, S
中科院分区：
文献类型：
--
作者：
Sogo, T;Fujisawa, T;Yokota, S
目的：评估与口服皮质类固醇治疗相比，静脉注射甲基强的松龙脉冲疗法（m-PSL）的疗效以及与口服皮质类固醇治疗相比，自身免疫性肝炎（AIH）儿童发生皮质类固醇相关副作用的情况。 研究设计：受试者由 9 名 AIH 儿童组成。患者被分为两组。第一组由 4 名接受常规口服泼尼松治疗但未接受 m-PSL 治疗的患者组成。第 2 组由 5 名儿童组成，他们接受 m-PSL 作为诱导治疗并维持口服泼尼松。结果：丙氨酸氨基转移酶正常化所需的中位持续时间在第 I 组中为 285 天（范围 18-617 天），在第 2 组中为 54 天（范围 15-116 天）。最常见的副作用是肥胖和生长迟缓。第I组的Z评分倾向于低于第2组，第I组的体重指数倾向于高于第2组。结论：m-PSL可能成为治疗AIH儿童的安全有效的疗法。需要进一步研究来确定儿童 AIH 的适当治疗方法。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Objective: To estimate an efficacy of intravenous methylprednisolone pulse therapy (m-PSL) and the occurrence of corticosteroid-related side effects in children with autoimmune hepatitis (AIH), compared with oral corticosteroid therapy.Study design: The subjects consisted of nine children with AIH. Patients were divided into two groups. Group I was consisted of four patients who were treated with conventional oral prednisone therapy without m-PSL. Group 2 was consisted of five children who were treated with m-PSL as an induction therapy and maintained on oral prednisone.Results: The median duration needed for normalization of alanine aminotransferase was 285 days (range 18-617 days) in group I and 54 days (range 15-116 days) in group 2. The most frequent side effects were obesity and growth retardation. The Z-score in group I tended to be lower than in group 2 and body mass index in group I tended to be higher than in group 2.Conclusion: The m-PSL may become a safe and effective therapy for children with AIH. Further study is needed to establish the appropriate therapy for AIH in children. (c) 2005 Elsevier Ireland Ltd. All rights reserved.