ULTRASTRUCTURE OF EBOLA VIRUS-PARTICLES IN HUMAN LIVER
ULTRASTRUCTURE OF EBOLA VIRUS-PARTICLES IN HUMAN LIVER
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DOI：
10.1136/jcp.31.3.201
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发表时间：
1978-01-01
影响因子：
3.4
通讯作者：
DENG, IM
中科院分区：
文献类型：
--
作者：
ELLIS, DS;SIMPSON, DIH;DENG, IM
在苏丹对埃博拉病毒感染患者进行的两次尸检的组织进行了电子显微镜检查，在肺和脾中发现了病毒颗粒，但在肝脏切片中发现了埃博拉病毒颗粒的主要浓度。在功能性肝细胞中发现了病毒前体蛋白和核心，通常以膜结合聚集体排列。完整的病毒体，通常只在细胞外发现，主要是长管状的形式，一些没有核心。许多管状的形式有“扩大的头”或“孢子”和一些分支和环面的形式被确定。埃博拉病毒的大小和结构似乎与马尔堡病毒几乎没有区别。
Electron microscopy of tissues from two necropsies carried out in the Sudan on patients with Ebola virus infection identified virus particles in lung and spleen, but the main concentrations of Ebola particles were seen in liver sections. Viral precursor proteins and cores were found in functional liver cells, often aligned in membrane-bound aggregations. Complete virions, usually found only extracellularly, were mainly seen as long tubular forms, some without cores. Many tubular forms had 'enlarged heads' or 'spores' and some branched and torus forms were identified. The size and structure of the Ebola virus forms appear to be virtually indistinguishable from those of Marburg virus.