Major stress in early childhood strengthens the association between peripheral inflammatory activity and corticostriatal responsivity to reward.
Major stress in early childhood strengthens the association between peripheral inflammatory activity and corticostriatal responsivity to reward.
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儿童早期的主要压力加强了外周炎症活动与皮质纹状体对奖励的反应之间的关联。
DOI：
10.1016/j.bbi.2024.01.013
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Nusslock,Robin
中科院分区：
文献类型：
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作者：
Miller,GregoryE;Carroll,AnnL;Armstrong,CaseyC;Craske,MichelleG;Zinbarg,RichardE;Bookheimer,SusanY;Ka-YiChat,Iris;Vinograd,Meghan;Young,KatherineS;Nusslock,Robin
研究背景童年时期严重的慢性压力会加重人一生中对心理和身体健康问题的脆弱性。为了解释这一现象，神经免疫网络假说提出，儿童期的压力源放大了外周炎症细胞和发育中的大脑回路之间的信号传导，这些回路支持奖励和威胁的处理。在这里，我们进行了初步的测试，这一假设的基本前提。方法180名青少年（平均年龄= 19.1岁; 68.9%的女性）与不同的种族和民族身份（56.1%的白色; 28.3%的西班牙裔; 26.1%的亚洲人）参与。童年创伤访谈被用来量化早期的逆境。在肘前血中检测了五种炎症生物标志物--C-反应蛋白、肿瘤坏死因子-a和白细胞介素-6、-8和-10--并取平均值以形成综合评分。参与者还完成了功能性MRI任务，以测量皮质纹状体的反应的预期和收购的monetaryrewards.ResultsStress曝光和皮质纹状体的反应相互作用的统计预测炎症复合物。在经历了主要的压力源在第一个十年的生活中，较高的炎症活动与较低的皮质纹状体反应性在收购的金钱奖励。这种关系是特定的参与者经历了重大的压力在幼儿期，这意味着一个敏感期暴露，并在眶额皮质和腹侧纹状体明显，这表明广泛参与皮质纹状体区域。研究结果是独立的参与者的年龄，性别，种族和民族身份，家庭收入，和抑郁症状。ConclusionsCollectively，结果是一致的假设表明，在童年的主要压力改变脑免疫信号。
BackgroundSevere, chronic stress during childhood accentuates vulnerability to mental and physical health problems across the lifespan. To explain this phenomenon, the neuroimmune network hypothesis proposes that childhood stressors amplify signaling between peripheral inflammatory cells and developing brain circuits that support processing of rewards and threats. Here, we conducted a preliminary test of the basic premises of this hypothesis.Methods180 adolescents (mean age = 19.1 years; 68.9 % female) with diverse racial and ethnic identities (56.1 % White; 28.3 % Hispanic; 26.1 % Asian) participated. The Childhood Trauma Interview was administered to quantify early adversity. Five inflammatory biomarkers were assayed in antecubital blood — C-reactive protein, tumor necrosis factor-a, and interleukins-6, −8, and −10 — and were averaged to form a composite score. Participants also completed a functional MRI task to measure corticostriatal responsivity to the anticipation and acquisition of monetary rewards.ResultsStress exposure and corticostriatal responsivity interacted statistically to predict the inflammation composite. Among participants who experienced major stressors in the first decade of life, higher inflammatory activity covaried with lower corticostriatal responsivity during acquisition of monetary rewards. This relationship was specific to participants who experienced major stress in early childhood, implying a sensitive period for exposure, and were evident in both the orbitofrontal cortex and the ventral striatum, suggesting the broad involvement of corticostriatal regions. The findings were independent of participants’ age, sex, racial and ethnic identity, family income, and depressive symptoms.ConclusionsCollectively, the results are consistent with hypotheses suggesting that major stress in childhood alters brain-immune signaling.